182153-22-6Relevant academic research and scientific papers
Dimethylzinc-mediated addition of alkenylzirconocenes to α-keto and α-imino esters
Wipf, Peter,Stephenson, Corey R. J.
, p. 2449 - 2452 (2003)
(Matrix presented) Hydrozirconation of alkynes followed by in situ transmetalation to dimethylzinc and 1,2-addition to activated ketones and N-diphenylphosphinoylimines leads to tertiary allylic alcohols and amines in high overall yield. With 8-phenylmenthol as the chiral auxiliary, si-face attack proceeds in good to excellent diastereoselectivities.
