182161-14-4Relevant academic research and scientific papers
Optically active 2H-azepines: Synthesis and rearrangement into their 3H-isomers
Hamprecht, Dieter,Joesten, Jakob,Steglich, Wolfgang
, p. 10883 - 10902 (1996)
A general synthesis of optically active 2H-azepines 12 starting from α-amino acids is described. The 2H-azepines easily rearrange into the corresponding 3H-isomers 18. The pungent taste of chalciporone (1) and simple 2,7-dialkylsubstituted 2H-azepines is due to the 2H-azepine nucleus and is independent of the absolute configuration at C-2.
