182161-95-1

Basic information

• Product Name: (5S,1'S)-N-[1'-(2-Furyl)butyl]-5-phenylmorpholin-2-one
• Synonyms: (5S,1'S)-N-[1'-(2-Furyl)butyl]-5-phenylmorpholin-2-one
• CAS NO: 182161-95-1
• Molecular Weight: 299.37
• Mol File: 182161-95-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (5S,1'S)-N-[1'-(2-Furyl)butyl]-5-phenylmorpholin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (5S,1'S)-N-[1'-(2-Furyl)butyl]-5-phenylmorpholin-2-one(182161-95-1)
• EPA Substance Registry System: (5S,1'S)-N-[1'-(2-Furyl)butyl]-5-phenylmorpholin-2-one(182161-95-1)

Safety Data

• Hazardous Substances Data: 182161-95-1(Hazardous Substances Data)

Upstream product

• 13331-23-2 fur-2-ylboronic acid 
• 144896-92-4 (5S)-5-phenylmorpholin-2-one 
• 123-72-8 butyraldehyde 

Downstream Products

• 308245-92-3 (R)-N-[1'-(2-Furyl)butyl]-N-[2-(p-tolylsulfonyloxy)ethyl]toluene-p-sulfonamide 
• 308246-02-8 (R)-N-[1'-(2-Furyl)butyl]-N-(2-phenylselenoethyl)toluene-p-sulfonamide 
• 158568-76-4 (R)-N-[1'-(2-Furyl)butyl]toluene-p-sulfonamide 
• 308245-71-8 (2S,1'R)-N-[1'-(2-Furyl)butyl]-N-(2-hydroxyethyl)-2-phenylglycinol 

Relevant articles and documents

Chirally templated boronic acid Mannich reaction in the synthesis of optically active α-amino acids

Adducts from diastereoselective Mannich-type reactions of aldehydes, 2-furylboronic acid and the chiral amine template (S)-5-phenylmorpholin-2-one, were used in the synthesis of a series of enantiomerically pure D-α-amino acids. The direction of diastereocontrol was proved by X-ray crystallography analysis of the reaction products. Results indicated that sequential degradation of diastereomically pure N-furfurylmorpholinones obtained by boronic Mannich condensation, could be carried out to produce amino acids of high optical purity.