182181-38-0

Basic information

• Product Name: 3-Fluoro-4-piperazinylbenzenecarbonitrile
• Synonyms: 3-Fluoro-4-piperazinylbenzenecarbonitrile;3-Fluoro-4-(1-piperazinyl)benzonitrile;3-Fluoro-4-piperazinylbenzonitrile;3-Fluoro-4-piperazinobenzonitrile;3-Fluoro-4-(piperazin-1-yl)benzonitrile;1-(4-Cyano-2-fluorophenyl)piperazine
• CAS NO: 182181-38-0
• Molecular Formula: C₁₁H₁₂FN₃
• Molecular Weight: 205.2315
• Product Categories: Amines and Anilines;Boron, Nitrile, Thio,& TM-Cpds
• Mol File: 182181-38-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 372.2 °C at 760 mmHg
• Flash Point: 178.9 °C
• Appearance: /
• Density: 1.23 g/cm³
• Vapor Pressure: 9.79E-06mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8?+-.0.10(Predicted)
• CAS DataBase Reference: 3-Fluoro-4-piperazinylbenzenecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoro-4-piperazinylbenzenecarbonitrile(182181-38-0)
• EPA Substance Registry System: 3-Fluoro-4-piperazinylbenzenecarbonitrile(182181-38-0)

Safety Data

• Hazardous Substances Data: 182181-38-0(Hazardous Substances Data)

Usage

General Description

3-Fluoro-4-piperazinylbenzenecarbonitrile is a chemical compound with the molecular formula C11H11FN4. It is a white to off-white crystalline solid that is used in the pharmaceutical industry as an intermediate for the synthesis of various pharmaceutical compounds. 3-Fluoro-4-piperazinylbenzenecarbonitrile contains a piperazine ring and a benzene ring with a fluoro group attached to the 3-position and a cyano group attached to the 4-position of the benzene ring. It is known for its potential as a drug candidate and has been studied for its antipsychotic and analgesic properties. Additionally, it has also been investigated for its potential use in treating depression, anxiety, and other neurological disorders.

InChI:InChI=1/C11H12FN3/c12-10-7-9(8-13)1-2-11(10)15-5-3-14-4-6-15/h1-2,7,14H,3-6H2

Upstream product

• 110-85-0 piperazine 
• 110888-15-8 4-chloro-3-fluorobenzonitrile 
• 929884-77-5 4-(4-cyano-2-fluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 64248-62-0 3,4-Difluorobenzonitrile 

Downstream Products

• 182180-92-3 4-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]-1-piperazinyl]-3-fluorobenzonitrile 
• 1236117-08-0 (S)-3-fluoro-4-(4-((6-oxo-5,6,6a,7,8,9-hexahydropyrido[3,2-e]pyrrolo[1,2-a]pyrazin-3-yl)methyl)piperazin-1-yl)benzonitrile 

Relevant articles and documents

QUINAZOLINONE COMPOUNDS AND RELATED COMPOUNDS

Disclosed are substituted quinazolinone compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions to treat diseases, disorders, or conditions such as those relating to unregulated protein functi

Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme

The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, and other diseases and conditions that are mediated by excessive glucocorticoid action.