1822-43-1Relevant articles and documents
Dynamic kinetic resolution of amines involving biocatalysis and in situ free radical mediated racemization
Gastaldi, Stephane,Escoubet, Stephanie,Vanthuyne, Nicolas,Gil, Gerard,Bertrand, Michele P.
, p. 837 - 839 (2007/10/03)
(Chemical Equation Presented) The association of lipase-catalyzed enzymatic resolution with in situ racemization mediated with the thiyl radical enables the dynamic kinetic resolution of non-benzylic amines. It leads to (R)-amides with high enantioselectivities. It can be applied either to the conversion of racemic mixtures or to the inversion of (S)-enantiomers.