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Usage

Uses

Used in Pharmaceutical Industry:
4-(Chloromethyl)piperidine hydrochloride is used as a synthetic reagent for the production of N-type calcium channel blocker (NP118809) derivatives. These derivatives are essential in the development of medications that help regulate calcium ion flow in cells, which can be beneficial for treating conditions such as hypertension, angina, and certain heart arrhythmias.

InChI:InChI=1/C6H12ClN/c7-5-6-1-3-8-4-2-6/h6,8H,1-5H2

Relevant academic research and scientific papers

Antipicornaviral pyridazinamines

Piperidinyl, pyrrolidinyl, azepinyl and piperazinyl pyridazines of formula STR1 wherein one or two carbon atoms of the STR2 moiety may be substituted with C1-4 alkyl, C1-4 alkyloxy or two carbon atoms of the CH2 groups of said moiety may be bridged with a C2-4 alkanediyl radical; X represents CH or N; R1 represents hydrogen, C1-4 alkyl, halo, hydroxy, trifluoromethyl, cyano, C1-4 alkyloxy, C1-4 alkylthio, C1-4 alkylsulfinyl, C1-4 alkylsulfonyl, C1-4 alkyloxycarbonyl, C1-4 alkylcarbonyl or aryl; R2 and R3 each independently represent hydrogen or C1-4 alkyl; Alk represents C1-4 alkanediyl; R4 and R5 each independently represent hydrogen, C1-4 alkyl or halo; and Het represents STR3 the addition salts and stereochemically isomeric forms thereof, said compounds having antipicornaviral activity. Pharmaceutical compositions containing these compounds as active ingredient, and a method of preparing said compounds and pharmaceutical compositions.