182201-54-3

Upstream product

• 103929-82-4 3,5-di-tert-butyldimethylsilyloxy-4-methoxybenzaldehyde 
• 60-18-4 L-tyrosine 
• 2937-50-0 Allyl chloroformate 
• 139517-75-2 (S)-methyl 2-(N-tert-butoxycarbonyl)(amino)-3-(3,5-dibromo-4-methoxyphenyl)propanoate 
• 203922-28-5 2-[1-[3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-meth-(E)-ylidene]-malonic acid monomethyl ester 

Downstream Products

• 182201-68-9 C₅₀H₅₄F₃N₃O₁₂SSi 
• 182201-67-8 C₄₈H₅₀F₃N₃O₁₁SSi 
• 203922-35-4 C₄₄H₄₈F₃N₃O₁₀SSi 
• 114899-80-8 (1'R,6R,6aR,7R,13S,14R,16R)-5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8-dihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinoline]-14-carbonitrile 
• 114899-77-3 ecteinascidin 743 
• 203922-36-5 C₄₄H₅₁N₃O₈Si 
• 182201-57-6 C₄₃H₆₁N₃O₁₀Si₂ 
• 203922-32-1 C₄₃H₆₃N₃O₁₀Si₂ 
• 182201-59-8 C₄₄H₅₁N₃O₇Si 
• 182201-65-6 C₄₀H₅₇N₃O₁₀Si₂ 
• 203922-33-2 C₃₁H₃₅N₃O₁₀ 
• 182201-56-5 {(S)-2-[3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-1-formyl-ethyl}-carbamic acid allyl ester 

Relevant academic research and scientific papers

Trabectedin intermediate preparation method

The invention discloses a trabectedin intermediate preparation method, which comprises: preparing a trabectedin intermediate (S)-2-(allyloxycarbonylamino)-3-(3,5-di(tert-butyldimethylsiloxy)-4-methoxyphenyl)propanoic acid by using tyrosine as a raw material. According to the present invention, the chiral source is directly introduced from the starting raw material, such that the use of chiral catalysis and chemical or enzymatic resolution in the reaction is avoided, the method has advantages of low production cost, high yield, easy purification, high purity and high optical purity of the obtained final product, and the like, the final product can be stored in large quantities, and the method is suitable for industrial production.