18226-11-4

Basic information

• Product Name: N-(2-hydroxyethyl)-2-nitrobenzenesulfonamide
• Synonyms: N-(2-hydroxyethyl)-2-nitrobenzenesulfonamide
• CAS NO: 18226-11-4
• Molecular Formula: C₈H₁₀N₂O₅S
• Molecular Weight: 246.24
• Mol File: 18226-11-4.mol
• Article Data: 14

Chemical Properties

• Melting Point: 83-85°
• Boiling Point: 462.2±55.0 °C(Predicted)
• Appearance: /
• Density: 1.484±0.06 g/cm3(Predicted)
• PKA: 9.78±0.40(Predicted)
• CAS DataBase Reference: N-(2-hydroxyethyl)-2-nitrobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-hydroxyethyl)-2-nitrobenzenesulfonamide(18226-11-4)
• EPA Substance Registry System: N-(2-hydroxyethyl)-2-nitrobenzenesulfonamide(18226-11-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 18226-11-4(Hazardous Substances Data)

Usage

Description

N-(2-hydroxyethyl)-2-nitrobenzenesulfonamide, a chemical compound with the molecular formula C8H10N2O5S, is a derivative of sulfanilamide and is commonly used in the pharmaceutical industry as a sulfa drug. It possesses antibacterial properties and is known for its ability to inhibit bacterial growth by interfering with the synthesis of essential molecules.

Uses

Used in Pharmaceutical Industry:
N-(2-hydroxyethyl)-2-nitrobenzenesulfonamide is used as a sulfa drug for its antibacterial properties, specifically targeting the synthesis of essential molecules in bacteria. It is often used in combination with other drugs to treat various bacterial infections.
Used in Chemical Synthesis:
N-(2-hydroxyethyl)-2-nitrobenzenesulfonamide serves as a chemical intermediate in the synthesis of other organic compounds, contributing to the development of new pharmaceuticals and chemical products.
Used in Dyes and Pigments Production:
In the production of dyes and pigments, N-(2-hydroxyethyl)-2-nitrobenzenesulfonamide is utilized as a chemical intermediate, playing a crucial role in the creation of various colorants for different industries.

Upstream product

• 141-43-5 ethanolamine 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 

Downstream Products

• 1636157-83-9 C₂₂H₂₁FN₂O₈S 
• 1636158-03-6 C₁₇H₁₅FN₂O₅S 
• 1589599-05-2 (S)-2-isopropyl-1-(4-methoxybenzyl)-4-(2-nitrophenylsulfonyl)piperazine 
• 1589599-14-3 2-hydroxy-N-[(2'S)-2'-{[(4-methoxyphenyl)methyl]amino}-3-methylbutyl]-S-(2'-nitrophenyl)ethane-1-sulfonamide 

Relevant articles and documents

MACROCYCLIC AMIDES ACTING AS PLASMEPSIN INHBITORS FOR THE TREATMENT OF MALARIA

The present invention relates to medicine and in particular to the treatment of malarial infections, more particularly to inhibitors of malarial aspartic proteases - plasmepsins. Even more particularly, the invention relates to macrocyclic amides and pharmaceutical compositions thereof and their use as inhibitors for plasmepsins (Plm).

Carbazole compounds and therapeutic uses of the compounds

Compounds of the general structural formula (I) and (II) and use of the compounds and salts and hydrates thereof, as therapeutic agents are disclosed. Treatable diseases and conditions include cancers, inflammatory diseases and conditions, and immunodeficiency diseases. (I), (II).

A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds

Piperazines are found widely in commercially-available compounds and bioactive molecules (including many drugs). However, in the vast majority of these molecules, the piperazine ring is isolated (i.e. not fused to another ring) and is not substituted on any of its carbon atoms. A modular synthetic approach is described in which combinations of cyclic sulfamidate and hydroxy sulfonamide building blocks may be converted into piperazines and related 1,4-diazepine and 1,5-diazocane scaffolds. By variation of the combinations of building blocks used, it was possible to vary the ring size, substitution and configuration of the resulting heterocyclic scaffolds. The approach was exemplified in the synthesis of a range of heterocyclic scaffolds that, on decoration, would target lead-like chemical space. It was demonstrated that lead-like small molecules based on these scaffolds would likely complement those found in large compound collections. This journal is the Partner Organisations 2014.