182293-01-2

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 939-70-8 2-acetylbenzimidazole 
• 16414-04-3 1-benzimidazol-2-ylethanol 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 1454686-99-7 N-(4-(2-(3-(1H-benzo[d]imidazol-2-yl)-5-(4-bromophenyl)-4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethoxy)phenyl)acetamide 

Relevant academic research and scientific papers

Design and structure-activity relationships anticandidosic of diazaheteroaryl functionalized by Micha?l acceptors

Benzimidazole and imidazopyridine heterocycles associated with Micha?l acceptors have shown strong anticandidosic potential in our previous work. After a decade of research, we have designed, synthesized and evaluated the anticandidosic activities of seve

A step-by-step synthesis of triazole-benzimidazole-chalcone hybrids: Anticancer activity in human cells+

Novel series of triazole-benzimidazole-chalcone hybrid compounds have been synthesized via click chemistry, between different azide derivatives and substituted benzimidazole terminal alkynes bearing a chalcone moiety. The starting alkynes are prepared via base-catalysed nitrogen alkylation of pre-synthetized benzimidazole-chalcone substrates. All the intermediates as well as the final products are fully characterized by 1D and 2D NMR and mass spectrometry techniques. HMBC correlations permits the identification of a unique 1,4-disubstitued triazole-benzimidazole-chalcone isomer. Evaluation of the anti-proliferative potential in breast and prostate cancer cell lines showed that the presence of chloro substituents at the chalcone ring of the triazole-benzimidazole-chalcone skeleton enhanced the cytotoxic effects. The benzyl group linked to the 1,2,3-triazole moiety provides more antiproliferative potential.

Synthesis and characterization of novel benzimidazole embedded 1,3,5-trisubstituted pyrazolines as antimicrobial agents

Efficient syntheses of some new substituted pyrazoline derivatives linked to substituted benzimidazole scaffold were performed by multistep reaction sequences. All the synthesized compounds were characterized using elemental analysis and spectral studies (IR, 1D/2D NMR techniques and mass spectrometry). The synthesized compounds were screened for their antimicrobial activity against selected Gram-positive and Gram-negative bacteria, and fungi strain. The compounds with halo substituted phenyl group at C5 of the 1-phenyl pyrazoline ring (15, 16 and 17) showed significant antibacterial activity. Among the screened compounds, 17 showed most potent inhibitory activity (MIC = 64 μg mL-1) against a bacterial strain. The tested compounds were found to be almost inactive against the fungal strain C. albicans, apart from pyrazoline-1-carbothiomide 21, which was moderately active.

Synthesis, characterization, and antimicrobial activity of benzimidazole-derived chalcones containing 1,3,4-oxadiazole moiety

A series of novel benzimidazole-derived chalcones containing the 1,3,4-oxadiazole moiety were synthesized and characterized by IR, 1H, 13C NMR, and mass spectra and elemental analysis. The synthesized compounds were evaluated for their efficiency as antibacterial agents against two Gram-positive and Gram-negative strains of bacteria along with antifungal activity against three fungal species. Antibacterial activity revealed that tested compounds exhibited potent activity whereas some compounds exhibited moderate antifungal activity as compared to the standards.

Synthesis and characterization of novel benzimidazole bearing pyrazoline derivatives as potential antimicrobial agents

A new series of compounds N-(4-(2-(3-(1H-benzo[d]imidazol-2-yl)-5-(aryl)-4, 5-dihydro-1H-pyrazol-1-yl)-2-oxoethoxy)phenyl)acetamides (5a-u) were synthesized and structures of these compounds were elucidated by spectral (IR, 1H NMR, 13C NMR, and mass spectra) analysis. Antimicrobial activity was measured against Escherichia coli (MTCC 443), Pseudomonas aeruginosa (MTCC 1688), Staphylococcus aureus (MTCC 96), Streptococcus pyogenes (MTCC 442), Candida albicans (MTCC 227), Aspergillus niger (MTCC 282), and Aspergillus clavatus (MTCC 1323) by serial broth dilution method. Evaluation of antimicrobial activity revealed that compounds 5f, 5i, 5q, and 5t were the most active antibacterial, while compounds 5e, 5g, 5h, 5j, 5p, 5r, and 5u were the most potent antifungal agents as compared to standard drugs and thus could be promising new lead molecules.

Synthesis Of 1H-benzo [D] imidazolo-2-Yl-3-Aryl-4- chlorocyclobutanone-2-Yl-Methanones, 1H-benzo [D] imidazolo-2-Yldihydro- 5-arylthiophen-3(2H)-One-2-yl-methanones, 4-(1H-benzo [D] imidazol-2-Yl)- 5,6-dihydro-6-arylpyrimidine-2(1H)-thiones and 4-(1H)- benzo [D] imidazol-2-Yl)-5,6-dihydro-6-arylpyrimidine-2-(1H)-ones

1-(1H-Benzo [d] imidazol-2-yl) ethanol (1) on treatment with acetic acid gave 1- (1H-benzo [d] imidazol-2-yl) ethanone (2). Compound 2 when treated with different aldehydes yielded arylidine derivatives (3a-e). Compound 3 on cyclization with chloroacetyl chloride, thioglycolic acid, thiourea and urea yielded azitidinones (4a-e) 4-thiazolidinones (5a-e), pyrimidinethiones (6a-d) and pyramidinones (7a-d) respectively. The structures of the products were established by spectral analysis like IR, 1H NMR and Mass spectroscopy.