1823-69-4

Basic information

• Product Name: N-[bis(dimethylamino)methylidene]-4-methylbenzenesulfonamide
• CAS NO: 1823-69-4
• Molecular Formula: C₁₂H₁₉N₃O₂S
• Molecular Weight: 269.3632
• Mol File: 1823-69-4.mol

Chemical Properties

• Boiling Point: 372.8°C at 760 mmHg
• Flash Point: 179.3°C
• Density: 1.12g/cm³
• Vapor Pressure: 9.39E-06mmHg at 25°C
• Refractive Index: 1.539
• CAS DataBase Reference: N-[bis(dimethylamino)methylidene]-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[bis(dimethylamino)methylidene]-4-methylbenzenesulfonamide(1823-69-4)
• EPA Substance Registry System: N-[bis(dimethylamino)methylidene]-4-methylbenzenesulfonamide(1823-69-4)

Safety Data

• Hazardous Substances Data: 1823-69-4(Hazardous Substances Data)

Upstream product

• 94790-37-1 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 
• 70-55-3 toluene-4-sulfonamide 
• 632-22-4 tetramethylurea 
• 4083-64-1 Tosyl isocyanate 
• 941-55-9 4-toluenesulfonyl azide 
• 2782-91-4 1,1,3,3-tetramethyl-2-thiourea 
• 98-59-9 p-toluenesulfonyl chloride 
• 80-70-6 N,N,N',N'-tetramethylguanidine 

Relevant articles and documents

Synthesis of Guanidine Derivatives and molecular recognition

Five Guanidine Derivatives bearing acyl group were synthesized by the reaction of acyl chloride with 1,1,3,3-tetramethylguanidine. Their structures were confirmed by IR, 1H-NMR, EI-MS, HRMS and elementary analysis. One of them (4a) was also cha

Facile one-pot synthesis of tetrasubstituted N-sulfonylguanidines from sulfonamides and ureas

A facile method for the synthesis of tetrasubstituted N-sulfonylguanidines has been developed via the direct condensation of sulfonamides and ureas in the presence of phosphoryl chloride under basic conditions. Detailed synthetic studies showed that this is a simple protocol for preparing N-sulfonylguanidines at room temperature in a short reaction time with good to excellent yields. Graphic abstract: [Figure not available: see fulltext.].

Method for synthesizing sulfaguani from tetra-substituted carbamide in one step

The invention discloses a method for synthesizing sulfaguani from tetra-substituted carbamide in one step. The method takes tetra-substituted carbamide and sulfonyl isocyanate as raw materials to react under a refluxing condition. After the reaction is fi

Efficient synthesis of sulfonylguanidines via reaction of tetra-substituted urine with ArSO2NCO

An efficient synthesis of sulfonylguanidines via reaction of tetra-substituted urines with ArSO2NCO has been developed with good yields, which provides a convenient way for synthesis of sulfonyl group protected guanidine from urine in one step.

Novel coupling reaction between sulfonyl azide and N,N,N',N'-tetramethylthiourea

The synthesis of sulfonylguanidines from N,N,N',N'-tetramethylthiourea and sulfonyl azides is described. This method serves as an alternative route for generating sulfonylguanidines via the use of stable starting materials.

N -Sulfonyl acetylketenimine as a highly reactive intermediate for the synthesis of N -sulfonyl amidines

A highly reactive intermediate N-sulfonyl acetylketenimine was generated from a 3-butyn-2-one participating CuAAC/ring-opening method. Its high reactivity due to bearing two EWGs allowed us to offer the first example of a reaction between ketenimine and amide to synthesize N-sulfonyl amidines efficiently.

Efficient synthesis of tetramethylsulfonylguanidines between a free sulfonamide group and HBTU

The reaction of a sulfonamide moiety with HBTU (O-(1H-benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate) during amide coupling, leading to the formation of tetramethylsulfonylguanidines, is described. Optimised conditions showed that HBT