18233-16-4Relevant academic research and scientific papers
Antibacterial drug for targeted therapy of staphylococcal infection by synergizing with antibiotic as well as synthesis method and application of antibacterial drug
-
, (2018/12/05)
The invention designs and synthesizes a novel antibacterial drug ASC for staphylococcus aureus based on a beta-lactam ring of a parent nucleus structure of beta-lactam antibiotic molecules, wherein the ASC is an antibacterial reagent and is also a broad-spectrum inhibitor of beta-lactam antibiotic drug-resistant target protein metal beta-lactamase; the ASC can synergize with three kinds of 7 to 8antibiotics such as beta-lactams, aminoglycosides and tetracyclines to carry out targeted therapy on the staphylococcal infection. The vitality of the antibiotics is increased by 4 to 128 times by combining with 1 [mu]g/ml dosage of ASC.
Four novel nanometer-sized cobalt azametallacrown complexes
Lin, Shen,Liu, Shi-Xiong,Huanga, Jian-Quan,Lina, Chi-Chang
, p. 1595 - 1601 (2007/10/03)
Four nanometer-sized cobalt azametallacrowns, [Co6(C8H6N3O3) 6(CH3OH)6]·10CH3OH ·2H2O (1), [Co6(C8H5N2O3) 6-(CH3OH)6]·5CH3OH ·0.5H2O (2), [Co6(C9H7N2O3) 6(CH3OH)6]·6CH3OH (3), and [Co6(C10H9N2O3) 6(CH3OH)6]·7CH3OH ·2H2O (4) have been synthesized by the self-assembly reaction of cobalt ions with N-substituted salicylhydrazide ligands. The cobalt atoms in the four azametallacrowns adopt a propeller configuration. The chiralities of the cobalt atoms alternate between the ∧ and Δ forms. In 1, there are two encapsulated methanol solvent molecules in the 'host' cavity of the azametallacrown molecule, whereas in 2-4 there are no guest molecules in the 'host' cavities of the azametallacrowns.
