18233-37-9

Basic information

• Product Name: 2-[2-(2,4-dichlorophenoxy)acetyl]-N-phenyl-1-hydrazinecarbothioamide
• Synonyms: 2-[2-(2,4-dichlorophenoxy)acetyl]-N-phenyl-1-hydrazinecarbothioamide;(E)-2-(2-(2,4-dichlorophenoxy)acetyl)-N-phenylhydrazine-1-carbimidothioic acid
• CAS NO: 18233-37-9
• Molecular Formula: C₁₅H₁₃Cl₂N₃O₂S
• Molecular Weight: 370.26
• Mol File: 18233-37-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[2-(2,4-dichlorophenoxy)acetyl]-N-phenyl-1-hydrazinecarbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(2,4-dichlorophenoxy)acetyl]-N-phenyl-1-hydrazinecarbothioamide(18233-37-9)
• EPA Substance Registry System: 2-[2-(2,4-dichlorophenoxy)acetyl]-N-phenyl-1-hydrazinecarbothioamide(18233-37-9)

Safety Data

• Hazardous Substances Data: 18233-37-9(Hazardous Substances Data)

Usage

General Description

2-[2-(2,4-dichlorophenoxy)acetyl]-N-phenyl-1-hydrazinecarbothioamide is a chemical compound with the molecular formula C14H11Cl2N3O2S. It is a hydrazine derivative that has potential use as a fungicide or herbicide due to its ability to inhibit fungal and plant enzyme systems. The compound contains both chlorophenyl and acetyl groups, which contribute to its bioactivity. Additionally, the presence of a hydrazinecarbothioamide moiety suggests that it may have potential as a thiol-reactive compound. Despite its potential applications, this chemical should be handled with caution and proper safety protocols, given its potential toxicity and reactivity.

Upstream product

• 94-75-7 2,4-Dichlorophenoxyacetic acid 
• 533-23-3 ethyl 2,4-dichlorophenoxyacetate 
• 103-72-0 phenyl isothiocyanate 
• 28236-62-6 2,4-dichlorophenoxyacetylhydrazine 

Downstream Products

• 21358-34-9 5-(2,4-dichlorophenoxymethyl)-4-phenyl-4H-1,2,4-triazole-3-thiol 
• 38376-47-5 5-((2,4-dichlorophenoxy)methyl)-2-(N-phenylamino)-1,3,4-thiadiazole 

Relevant articles and documents

Novel 2,4-dichlorophenoxy acetic acid substituted thiazolidin-4-ones as anti-inflammatory agents: Design, synthesis and biological screening

A library of fourteen 2-imino-4-thiazolidinone derivatives (1a-1n) has been synthesized and evaluated for in vivo anti-inflammatory activity and effect on ex-vivo COX-2 and TNF–α expression. Compounds 1k (5-(2,4-dichloro-phenooxy)-acetic acid (3-benzyl-4-oxo-thiazolidin-2-ylidene)-hydrazide) and 1m (5-(2,4-dichloro-phenooxy)-acetic acid (3-cyclohexyl-4-oxo-thiazolidin-2-ylidene)-hydrazide) exhibited in vivo inhibition of 81.14% and 78.80% respectively after 5 h in comparison to indomethacin which showed 76.36% inhibition of inflammation without causing any damage to the stomach. Compound 1k showed a reduction of 68.32% in the level of COX-2 as compared to the indomethacin which exhibited 66.23% inhibition of COX-2. The selectivity index of compound 1k was found to be 29.00 in comparison to indomethacin showing selectivity index of 0.476. Compounds 1k and 1m were also found to significantly suppress TNF-α concentration to 70.10% and 68.43% in comparison to indomethacin which exhibited 66.45% suppression.