182344-13-4

Usage

Uses

suzuki reaction

InChI:InChI=1/C6H6BClO3/c8-5-3-4(7(10)11)1-2-6(5)9/h1-3,9-11H

Upstream product

• 3964-56-5 4-bromo-2-chlorophenol 

Downstream Products

• 1214320-25-8 6-((1H-1,2,4-triazol-1-yl)methyl)-3'-chloro-4'-hydroxybiphenyl-3-carbonitrile 
• 1255939-97-9 [5-(3-chloro-4-hydroxyphenyl)-2-thienyl](3-hydroxyphenyl)methanone 
• 1357563-67-7 (3'-chloro-4'-hydroxybiphenyl-4-yl)-(3-methoxyphenyl)-methanone 
• 1357564-23-8 [6-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-(3-methoxyphenyl)-methanone 
• 1357563-52-0 [6-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-(3-hydroxyphenyl)-methanone 
• 1357563-77-9 (3'-chloro-4'-hydroxybiphenyl-4-yl)-(4-fluoro-3-methoxyphenyl)-methanone 
• 1357563-38-2 (3'-chloro-4'-hydroxybiphenyl-4-yl)-(4-fluoro-3-hydroxyphenyl)-methanone 
• 1357564-05-6 (4-fluoro-3-methoxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone 
• 1357563-44-0 (4-fluoro-3-hydroxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone 
• 1416217-84-9 4'-[4-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl)piperazin-1-yl]-3-chloro-[1,1'-biphenyl]-4-ol 

Relevant academic research and scientific papers

1,2,4-TRIAZOL-l-YL BISPHENYL DERIVATIVES FOR USE IN THE TREATMENT OF ENDOCRINE-DEPENDENT TUMOURS

There is provided a compound of Formula I wherein R3, R4, R5, R6 and R7 are independently selected from H and -Y-R6; wherein each R8 is independently selected from -OH, hydrocarbyl groups, oxyhydrocarbyl groups, cyano (-CN), nitro (-NO2), H-bond acceptors, and halogens; wherein at Jeast one of R3, R4, R5, R6 and R7 is -Y-R8 wherein R8 is selected from substituted and unsubstituted ? heterocyclic rings and amino substituted phenyl groups, wherein X is a bond or a linker group; wherein Y is an optional linker group; and wherein ring A is optionally further , substituted; wherein R9 is selected from H, -OH and -OSO2NR1R2; wherein R1 and R2 are independently selected from H and hydrocarbyl; wherein (a) X is a bond and at least one of R3, R4, R5, R6 and R7 is -Y-R8; OR (b) R9 is -OSO2NR1R2 or - OH and four of R3, R4, R5, R6 and R7 are H and one of R3, R4, R5, R6 and R7 is -Y-R8. These compounds inhibit steroid sulphatase and aronatase activity and are useful in the treatment of endocrine-dependent tumours.

Biomarkers for phenol carcinogen exposure act as pH-sensing fluorescent probes

Biomarkers for phenolic carcinogen exposure, 8-(4″)-hydroxyphenyl)-2′-deoxypurines, have been found to possess pH-sensitive fluorescent properties. Phenolic ionization constants (pKa) establish substituent (σ-) constants of 0.46 for