182352-44-9Relevant academic research and scientific papers
A facile solid phase synthesis of tetramic acid
Liu, Zhanxiang,Ruan, Xiuxiu,Huang, Xian
, p. 2505 - 2507 (2007/10/03)
The condensation of N-acylated amino acids with polymer-supported cyclic malonic acid ester was carried out in the presence of DCC/DMAP. The cyclisation of the intermediate resin, by heating in an organic solvent, gave the N-protected tetramic acid derivatives in good yields and high purity.
Acylaminoacetyl derivatives of active methylene compounds. 4. Synthesis of N-protected tetramic acids via the C-acylation reaction of Meldrum's acid with the imidazolides of N-protected glycines
Hamilakis,Kontonassios,Sandris
, p. 825 - 829 (2007/10/03)
Meldrum's acid has been found to be effectively acylated using the imidazolides of N-protected glycines, X-NHCH2COOH (X = -COPh, -COMe, -Z, -Boc, -COOMe and -COOEt). The corresponding C-acylation compounds were isolated in high yields and were
