18242-39-2Relevant articles and documents
Syntheses and characterizations of high refractive index and low birefringence polyimides containing spirobifluorene in the side chain
Wen, Pushan,He, Rui,Li, Xiang-Dan,Lee, Myong-Hoon
, p. 76 - 83 (2017)
Two new diamine monomers having a spirobifluorene structure were synthesized through four steps, and polymerized with three different dianhydrides (PMDA, CBDA and 6FDA) to obtain six polyimides with spirobifluorene structure in the side chain. All the res
Role of electron-withdrawing remote substituents in neutral nickel(II) polymerization catalysts
Osichow, Anna,Goettker-Schnetmann, Inigo,Mecking, Stefan
, p. 5239 - 5242 (2013)
The novel neutral κ2-N,O-salicylaldiminato Ni(II) complex, [κ2-N,O-{2,6-(3′,5′-R2C 6H3)2C6H3-N=C(H)-(3,5- I2-2-O-C6H2)}NiCH3/sub
Transformative binding and release of gold guests from a self-assembled Cu8L4 tube
Meng, Wenjing,Clegg, Jack K.,Nitschke, Jonathan R.
, p. 1881 - 1884 (2012)
Totally tubular: A linear M8L48+ receptor, which binds tightly and selectively to the dicyanoaurate anion, was assembled from simple organic subcomponents and copper(I) ions. The guest complex is not bound unchanged, but instead is transformed into a longer linear complex where two dicyanogold units are bridged by a central cation of copper/silver (see scheme). This complex optimally fills the cavity of the receptor but is not observed in the absence of the host.
Elastic orange emissive single crystals of 1,3-diamino-2,4,5,6-tetrabromobenzene as flexible optical waveguides
Bhaktha B. N., Shivakiran,Biradha, Kumar,Choubey, Priyanka S.,Das, Susobhan,Gude, Venkatesh,Reddy, C. Malla
supporting information, p. 9465 - 9472 (2021/08/10)
Single crystals of monoaromatic compounds exhibiting both mechanical softness and optical properties have attracted significant scientific interest in recent years, but they are very scarce. Herein, single crystals of 1,3-diamino-2,4,5,6-tetrabromobenzene
Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds
Pallesen, Jakob S.,Narayanan, Dilip,Tran, Kim T.,Solbak, Sara M. ?.,Marseglia, Giuseppe,S?rensen, Louis M. E.,H?j, Lars J.,Munafò, Federico,Carmona, Rosa M. C.,Garcia, Anthony D.,Desu, Haritha L.,Brambilla, Roberta,Johansen, Tommy N.,Popowicz, Grzegorz M.,Sattler, Michael,Gajhede, Michael,Bach, Anders
supporting information, p. 4623 - 4661 (2021/05/07)
Targeting the protein-protein interaction (PPI) between nuclear factor erythroid 2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) is a potential therapeutic strategy to control diseases involving oxidative stress. Here, six classes of known small-molecule Keap1-Nrf2 PPI inhibitors were dissected into 77 fragments in a fragment-based deconstruction reconstruction (FBDR) study and tested in four orthogonal assays. This gave 17 fragment hits of which six were shown by X-ray crystallography to bind in the Keap1 Kelch binding pocket. Two hits were merged into compound 8 with a 220-380-fold stronger affinity (Ki = 16 μM) relative to the parent fragments. Systematic optimization resulted in several novel analogues with Ki values of 0.04-0.5 μM, binding modes determined by X-ray crystallography, and enhanced microsomal stability. This demonstrates how FBDR can be used to find new fragment hits, elucidate important ligand-protein interactions, and identify new potent inhibitors of the Keap1-Nrf2 PPI.
Indole compound as well as preparation method, pharmaceutical composition and application thereof
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Paragraph 0551-0556, (2019/12/02)
The invention discloses an indole compound as well as a preparation method, a pharmaceutical composition and an application thereof. Specifically, the invention relates to an indole derivative as shown in a general formula I and a medicinal salt thereof, a preparation method of the indole derivative, a composition containing one or more compounds, and applications of the compounds in preparation of medicines for preventing and/or treating diseases related to IDO1 and/or TDO.
