182438-98-8

Basic information

• Product Name: 9-(4-broMobutyl)-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxaMide
• Synonyms: 9-(4-broMobutyl)-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxaMide;9-(4-bromobutyl)-N-(2,2,2-trifluoroethyl)fluorene-9-carboxamide
• CAS NO: 182438-98-8
• Molecular Formula: C₂₀H₁₉BrF₃NO
• Molecular Weight: 426.2701696
• Mol File: 182438-98-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 531.3±50.0 °C(Predicted)
• Appearance: /
• Density: 1.404±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.61±0.20(Predicted)
• CAS DataBase Reference: 9-(4-broMobutyl)-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 9-(4-broMobutyl)-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxaMide(182438-98-8)
• EPA Substance Registry System: 9-(4-broMobutyl)-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxaMide(182438-98-8)

Safety Data

• Hazardous Substances Data: 182438-98-8(Hazardous Substances Data)

Usage

General Description

9-(4-bromobutyl)-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide is a chemical compound that belongs to the class of amides. It consists of a fluorene core with a carboxamide group attached to it, as well as a 4-bromobutyl and a 2,2,2-trifluoroethyl substituent. 9-(4-broMobutyl)-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxaMide has potential applications in the field of organic synthesis and drug development due to its unique structure and properties. It may also have uses in materials science and as a reagent in chemical reactions. However, it is important to handle and use this chemical with caution, following appropriate safety protocols and guidelines.

Upstream product

• 1989-33-9 9H-fluorene-9-carboxylic acid 
• 373-88-6 2,2,2-trifluroethylamine hydrochloride 
• 182438-97-7 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid 
• 110-52-1 1,4-dibromo-butane 
• 753-90-2 trifluoroethylamine 
• 331767-53-4 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid chloride 

Downstream Products

• 331767-10-3 9-[4-(4-phenyl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoro-ethyl)-amide 
• 331767-11-4 9-[4-(4-biphenyl-3-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide 
• 331767-13-6 9-[4-(4-biphenyl-4-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide 
• 331767-15-8 9-{4-[4-(4-Chloro-phenyl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide 
• 331767-16-9 9-{4-[4-(3-Chloro-phenyl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide 
• 331767-18-1 9-{4-[4-(4-Benzyloxy-phenyl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide 
• 331767-19-2 9-{4-[4-(4-Trifluoromethyl-phenyl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide 
• 331767-20-5 9-{4-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide 
• 331767-22-7 9-{4-[4-(4-Fluorophenyl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide 
• 331767-24-9 9-{4-[4-(4-Chloro-3-trifluoromethyl-phenyl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide 
• 331767-25-0 9-{4-[4-(4-methyl-phenyl)-3-methyl-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide 
• 331767-26-1 9-{4-[4-(3,4-dichlorophenyl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide 
• 331767-27-2 9-{4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide 
• 331767-28-3 9-{4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide 

Relevant articles and documents

CRYSTALLINE POLYMORPH OF N-(2,2,2-TRIFLUOROETHYL-9-[4-[R4-R[[[I4'- (TRIFLUOROMETHYL) [ 1,1 ' -BIPHENYL] -2-YL] CARBONYL] AMINO] -1 -PIPERIDINYL] BUTYL] -9H- FLUORENE-9-CARBOXAMIDE METHANESULFONATE AND PROCESS FOR PREPARATION THEREOF

The present invention relates to? crystalline polymorph of N-(2,2.2-trifluoroethyl)-9- [4- [4- [ [[4,-(trifluoromethyl) [1,1 '-biphenyl] -2-yl] carbonyl] amino] - 1 -piperidinyl] butyl] -9H- fluorene-9-carboxamide methanesulfonate salt represented by the following structural formula- la and process for preparation thereof.

Method for synthesizing triglyceride transfer protease inhibitor

The invention discloses a method for synthesizing the triglyceride transfer protease inhibitor Lomitapide. Specifically, based on improvement of an existing technique, the compounds 9-carboxyfluorene and 1,4-dibromobutane are used as raw materials, five-step reaction is conducted, and the defects of the prior art are overcome. Compared with the prior art, the method has the main advantage that column chromatography purification is avoided, and product purification is conducted with a recrystallization method which is economical and environment-friendly.

PROCESS FOR THE PREPARATION OF LOMITAPIDE

The present invention relates to a process for preparing Lomitapide or its pharmaceutically acceptable salt thereof having high purity with acceptable levels of impurities.