182564-41-6 Usage
Uses
Different sources of media describe the Uses of 182564-41-6 differently. You can refer to the following data:
1. N-(4-Fluorobenzoyl)-5-amino-1H-indole is a octamer-binding transcription factor 4 activating compound that activated Oct4 and Nanog promoters, which are essential regulators of embryonic stem cell (ESC) pluripotency and key to the reprogramming process.
2. Octamer-binding transcription factor 4 (Oct4) is a transcription factor which, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells. OAC3 is an Oct4-activating compound which activates expression through the Oct4 gene promoter. In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC3 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells from embryonic fibroblasts.[Cayman Chemical]
Check Digit Verification of cas no
The CAS Registry Mumber 182564-41-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,2,5,6 and 4 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 182564-41:
(8*1)+(7*8)+(6*2)+(5*5)+(4*6)+(3*4)+(2*4)+(1*1)=146
146 % 10 = 6
So 182564-41-6 is a valid CAS Registry Number.
182564-41-6Relevant articles and documents
Designing selective, high affinity ligands of 5-HT1D receptor by covalent dimerization of 5-HT1F ligands derived from 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide
Choi, Seok-Ki,Green, David,Ho, Anne,Klein, Uwe,Marquess, Daniel,Taylor, Robert,Turner, S. Derek
supporting information; experimental part, p. 3609 - 3616 (2009/04/07)
We demonstrate here that covalent dimerization of 5-HT1 ligands is an effective design strategy to modulate affinity and selectivity of 5-HT1 ligands. This approach was applied to LY-334370, a selective agonist of 5-HT1F r
5-SUBSTITUTED-3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)-AND 3-(PIPERIDIN-4-YL)-1H-INDOLES: NEW 5-HT1F AGONISTS
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, (2008/06/13)
This invention provides novel 5-HT 1F agonists of Formula I STR1 where A--B, R, R 1 and X are as defined in the specification, which are useful for the treatment of migraine and associated disorders.
Use of a serotonin 5-HTlf agonist in the manufacture of a medicament for treating or ameliorating the symptoms of common cold or allergic rhinitis
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, (2008/06/13)
This invention provides methods for the treatment or amelioration of the symptoms of the common cold or allergic rhinitis which comprises administering to a mammal in need thereof a serotonin 5-HT1F agonist.
