18259-12-6

Upstream product

• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 830-79-5 2,4,6-trimethoxybenzaldehyde 
• 21852-32-4 4-bromomethyl-1,2-dimethoxybenzene 
• 7306-46-9 4-chloromethyl-1,2-dimethoxy-benzene 
• 78055-65-9 diethyl (3,4-dimethoxybenzyl)phosphonate 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 

Downstream Products

• 621-23-8 1,2,3-trimethoxybenzene 
• 19611-17-7 2-(3',4'-dimethoxyphenyl)-6,7-dimethoxynaphthalene 

Relevant academic research and scientific papers

Effect of methoxy stilbenes—analogs of resveratrol—on the viability and induction of cell cycle arrest and apoptosis in human myeloid leukemia cells

The present study aimed to evaluate the cytotoxicity and its mechanism of five synthetic methoxy stilbenes, namely 3,4,4?-trimethoxy, 3,4,2?-trimethoxy, 3,4,2?,4?-tetramethoxy, 3,4,2?,6?-tetramethoxy, and 3,4,2?,4?,6?-pentamethoxy-trans-stilbenes (MS), in

Synthesis of 2-phenylnaphthalenes from styryl-2-methoxybenzenes

A new simple and efficient method for the synthesis of 2-phenylnaphthalenes from electron-rich 1-styryl-2-methoxybenzenes has been described. The reaction proceeds via TFA catalyzed C-C bond cleavage followed by intermolecular [4+2]-Diels-Alder cycloaddition of an in situ formed styrenyl trifluoroacetate intermediate. The quantum chemical calculations identified the transition state for the cycloaddition reaction and helped in tracing the reaction mechanism. The method has been efficiently utilized for synthesis of the phenanthrene skeleton and a naphthalene-based potent and selective ER-β agonist. This journal is

3,4,2′-Trimethoxy-trans-stilbene-a potent CYP1B1 inhibitor

A novel series of methoxy-trans-stilbenes with 3,4-dimethoxy motifs was designed and synthesized. The inhibitory potency of 3,4-dimethoxystilbene derivatives against cytochrome P450 isozymes CYP1A1, CYP1B1 and CYP1A2 was evaluated. 3,4,2′-Trimethoxy-trans-stilbene (3,4,2′-TMS) exhibited extremely potent inhibitory action against CYP1B1 activity with an IC 50 of 0.004 μM. 3,4,2′-TMS exhibited 90-fold selectivity for CYP1B1 over CYP1A1 and 830-fold selectivity for CYP1B1 over CYP1A2. However, 3,4,2′,4′-tetramethoxy-trans-stilbene appeared to be the most selective inhibitor of both CYP1B1 and CYP1A1 showing very low affinity toward CYP1A2. Complementary experimental studies and computational methods were used to explain what structural determinants decide the specific affinity of stilbene derivatives to CYP1A2 and CYP1B1 binding sites.