182617-06-7

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 215160-79-5 (3S)-5-benzyloxy-3-(4-methoxybenzyloxy)pentanal 
• 182617-03-4 (E)-(R)-7-Benzyloxy-5-(4-methoxy-benzyloxy)-2-methyl-hept-2-enoic acid ethyl ester 
• 182617-20-5 2-[(S)-4-Benzyloxy-2-(4-methoxy-benzyloxy)-butyl]-[1,3]dithiane 
• 182617-05-6 {(2S,3S)-3-[(S)-4-Benzyloxy-2-(4-methoxy-benzyloxy)-butyl]-2-methyl-oxiranyl}-methanol 
• 182617-04-5 (E)-(R)-7-Benzyloxy-5-(4-methoxy-benzyloxy)-2-methyl-hept-2-en-1-ol 
• 173279-16-8 (S)-4-Benzyloxy-1-[1,3]dithian-2-yl-butan-2-ol 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 182617-18-1 (E)-(4S,5R,6S)-6-{(4R,6S)-6-[(1R,2S,4S)-6-Benzyloxy-2-methoxy-4-(4-methoxy-benzyloxy)-1-methyl-hexyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-5-(tert-butyl-dimethyl-silanyloxy)-4-methyl-hept-2-enoic acid ethyl ester 
• 182617-16-9 (E)-3-[(2S,3S)-3-((S)-1-{(4R,6S)-6-[(1R,2S,4S)-6-Benzyloxy-2-methoxy-4-(4-methoxy-benzyloxy)-1-methyl-hexyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-2-methyl-oxiranyl]-acrylic acid ethyl ester 
• 182617-13-6 (E)-3-{(2R,3R)-3-[(2S,3R,4S,6S)-8-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-6-(4-methoxy-benzyloxy)-3-methyl-octyl]-2-methyl-oxiranyl}-2-methyl-acrylic acid ethyl ester 
• 182617-14-7 (E)-(4R,5R,7S,8R,9S,11S)-13-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-9-methoxy-11-(4-methoxy-benzyloxy)-2,4,8-trimethyl-tridec-2-enoic acid ethyl ester 
• 182571-79-5 (2R,3S,4S)-4-{(4R,6S)-6-[(1R,2S,4S)-6-Benzyloxy-2-methoxy-4-(4-methoxy-benzyloxy)-1-methyl-hexyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-pentanal 
• 182617-17-0 (E)-(4S,5R,6R)-6-{(4R,6S)-6-[(1R,2S,4S)-6-Benzyloxy-2-methoxy-4-(4-methoxy-benzyloxy)-1-methyl-hexyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-5-hydroxy-4-methyl-hept-2-enoic acid ethyl ester 
• 182617-15-8 (E)-(R)-4-{(4R,6S)-6-[(1R,2S,4S)-6-Benzyloxy-2-methoxy-4-(4-methoxy-benzyloxy)-1-methyl-hexyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-2-methyl-pent-2-enoic acid ethyl ester 
• 182617-21-6 (E)-(5S,6R,7S,9S)-11-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-7-methoxy-9-(4-methoxy-benzyloxy)-2,6-dimethyl-undec-2-enoic acid ethyl ester 
• 182617-26-1 [(2S,3S)-3-((S)-1-{(4R,6S)-6-[(1R,2S,4S)-6-Benzyloxy-2-methoxy-4-(4-methoxy-benzyloxy)-1-methyl-hexyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-2-methyl-oxiranyl]-methanol 
• 182617-24-9 (E)-(4R,5R,7S,8S,9S,11S)-13-Benzyloxy-5,7-dihydroxy-9-methoxy-11-(4-methoxy-benzyloxy)-2,4,8-trimethyl-tridec-2-enoic acid ethyl ester 
• 182617-23-8 {(2R,3R)-3-[(2S,3R,4S,6S)-8-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-6-(4-methoxy-benzyloxy)-3-methyl-octyl]-2-methyl-oxiranyl}-methanol 
• 182617-25-0 (E)-(R)-4-{(4R,6S)-6-[(1R,2S,4S)-6-Benzyloxy-2-methoxy-4-(4-methoxy-benzyloxy)-1-methyl-hexyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-2-methyl-pent-2-en-1-ol 
• 182617-22-7 (E)-(5S,6R,7S,9S)-11-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-7-methoxy-9-(4-methoxy-benzyloxy)-2,6-dimethyl-undec-2-en-1-ol 
• 182617-12-5 (E)-(5S,6S,7S,9S)-11-Benzyloxy-5-hydroxy-7-methoxy-9-(4-methoxy-benzyloxy)-2,6-dimethyl-undec-2-enoic acid ethyl ester 

Relevant academic research and scientific papers

Total synthesis of preswinholide A. 1. Stereoselective synthesis of the C11-C23 segment

The C11-C23 segment of preswinholide A was stereoselectively synthesized based on the iterative construction of 1,3-polyol chains using a series of sequential reactions which involves the Sharpless asymmetric epoxidation of allyl alcohol and Pd-catalyzed hydrogenolysis of alkenyl oxirane with HCOOH as the key reactions.