182622-12-4Relevant academic research and scientific papers
Utilization of Wieland furoxan synthesis for preparation of 4-aryl-1,2,5-oxadiazole-3-yl carbamate derivatives having potent anti-HIV activity
Takayama, Hiromitsu,Shirakawa, Seiichiro,Kitajima, Mariko,Aimi, Norio,Yamaguchi, Kentaro,Hanasaki, Yasuaki,Ide, Teruhiko,Katsuura, Kimio,Fujiwara, Masatoshi,Ijichi, Katsushi,Konno, Kenji,Sigeta, Shiro,Yokota, Tomoyuki,Baba, Masanori
, p. 1993 - 1996 (1996)
The classical Wieland furoxan synthesis was reinvestigated and this procedure was applied to the preparation of 4-aryl-1,2,5-oxadiazole-3-yl N,N-dialkylcarbamate derivatives, which were found to exhibit potent anti-HIV-1 activity.
Synthesis of alkynyl furoxans. Rare carbon-carbon bond-forming reaction on a furoxan ring
Matsubara, Ryosuke,Eguchi, Shuhei,Ando, Akihiro,Hayashi, Masahiko
, p. 1965 - 1969 (2017)
A rare carbon-carbon-bond forming reaction on a furoxan ring has been developed. The nucleophilic aromatic substitution (SNAr) reaction of 4-nitrofuroxans with alkynyl lithium proceeded with high yields, which enabled the first practical synthesis of both alkynyl furoxan regioisomers. Due to the versatility of the alkyne functional group, various derivatizations of the carbon-carbon triple bond in the afforded products were possible. Thus, this developed method is a convergent approach to a wide spectrum of carbon-substituted furoxans.
