18266-62-1

Upstream product

• 90-05-1 2-methoxy-phenol 
• 563-47-3 3-Chloro-2-methylpropene 

Downstream Products

• 107970-07-0 1-((E)-3-Bromo-2-methyl-allyloxy)-2-methoxy-benzene 
• 107970-13-8 1-(2,3-Dibromo-2-methyl-propoxy)-2-methoxy-benzene 

Relevant academic research and scientific papers

Preparation of chiral building blocks for a highly convergent vitamin E synthesis. Systematic investigations on the enantioselectivity of the sharpless bishydroxylation

The enantioselective bishydroxylation of protected 2-methylprop-2-enol 15 and 3-methylbut-3-en-1-ol 16 to give the corresponding diols 18 and 19, respectively, which can be transformed into building blocks for the synthesis of natural vitamin E, is described. It is shown that the enantioselectivity of the bishydroxylation reaction clearly depends on the type of protecting group and its distance from the alkene moiety, with 96% ee for 16a and 16f as the best and 8% ee for 15d as the lowest result.

FUROISOQUINOLINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND USE THEREOF

A compound having a partial structure represented by Formula: or a salt thereof has an excellent phosphodiesterase (PDE) IV-inhibiting effect, and is useful as a prophylactic or therapeutic agent against inflammatory diseases, for example, bronchial asthma, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, autoimmune disease, diabetes and the like.