182682-74-2Relevant academic research and scientific papers
Synthesis of Some New Nitrogenous Derivatives of Glycyrrhetic Acid with Potential Biological Activity
Ibrahim, Yehia Abdu,Hanna, Atef G.,Elgamal, M. Hani A.,Allam, R. F.,Youssef, Khaled A. M.
, p. 101 - 107 (2007/10/03)
The synthesis of some nitrogenous derivatives from glycyrrhetic acid hydrazides (III) by incorporating its C-30 to form 1',3',4'-oxadiazole (V), 4'-acetyl-5-aryl-1'-oxadiazoline (VII), 1',3',4'-triazole (X), carboxymethyl thiotriazole (XII) and 1',3',4'-thiodiazoline-5'-thion (XIII) rings are reported.The reactions of the hydrazide III with aromatic aldehydes, thiocyanates, isocyanates and its 3-acetyl derivative (XVI) with aniline and ethyl glycinate were studied.The antimicrobial activity of some derivatives was tested against some microorganisms. - Key Words: Glycyrrhetic acid; Oxadiazole; Triazole; Thiodiazole derivatives.
