182691-17-4Relevant academic research and scientific papers
Lipase-catalyzed enantioselective acylation of prochiral 2-(ω)-phosphono)alkyl-1,3-propanediols: Application to the enantioselective synthesis of ω-phosphono-α-amino acids
Yokomatsu, Tsutomu,Sato, Mutsumi,Shibuya, Shiroshi
, p. 2743 - 2754 (2007/10/03)
Lipase PS catalyzed acetylation of prochiral 2-(ω-phosphono)alkyl-1,3-propanediols 1a-c was found to proceed with high enantioselectivity. The applications of phosphonic chirons 2a-c thus obtained were illustrated by the stereocontrolled synthesis of ω-phosphono-α-amino acids such as L-AP-3, L-AP-4, and N-Boc-L-F2Pab(OEt)2-OH.
