18276-86-3Relevant academic research and scientific papers
Copper-Catalyzed Direct Oxyphosphorylation of Enamides with P(O)-H Compounds and Dioxygen
Liang, Wu,Zhang, Zhijie,Yi, Dong,Fu, Qiang,Chen, Suyuan,Yang, Lu,Du, Fengtian,Ji, Jianxin,Wei, Wei
supporting information, p. 1378 - 138 (2017/10/06)
A simple and convenient copper-catalyzed direct oxyphosphorylation of enamides with P(O)-H compounds and dioxygen has been developed under mild conditions. This methodology can allow the synthesis of a series of valuable β-ketophosphine oxides/β-ketophosphonates in moderate to good yields with a broad substrate scope simply by using readily-available starting materials.
A one-pot strategy to synthesize β-ketophosphonates: Silver/copper catalyzed direct oxyphosphorylation of alkynes with H-phosphonates and oxygen in the air
Chen, Xin,Li, Xu,Chen, Xiao-Lan,Qu, Ling-Bo,Chen, Jian-Yu,Sun, Kai,Liu, Zhi-Dong,Bi, Wen-Zhu,Xia, Ying-Ya,Wu, Hai-Tao,Zhao, Yu-Fen
supporting information, p. 3846 - 3849 (2015/03/30)
A highly efficient one-pot strategy has been developed for the synthesis of β-ketophosphonates directly from alkynes and dialkyl H-phosphonates in the presence of widely available AgNO3/CuSO4 and K2S2O8 at room temperature under open-air conditions.
Synthetic entry into 1-phosphono-3-azabicyclo[3.1.0]hexanes
Debrouwer, Wouter,Heugebaert, Thomas S. A.,Van Hecke, Kristof,Stevens, Christian V.
, p. 8232 - 8241 (2013/09/24)
3-Azabicyclo[3.1.0]hex-2-en-1-yl phosphonates were prepared in a five-step reaction route from β-ketophosphonates. The key steps in this sequence are an atom-transfer radical cyclization and an unforeseen lithium-halogen exchange with n-BuLi. The cyclization reaction proceeds with excellent diastereoselectivity. The resulting cyclic imines were reduced, and 3-azabicyclo[3.1.0]hexan-1-yl phosphonates were obtained.
