18276-98-7Relevant academic research and scientific papers
Highly Efficient Synthesis of α-Halomethylketones via Ce(SO4)2/Acid Co-Catalyzed Hydration of Alkynes
Zou, Huaxu,Jiang, Jun,Yi, Niannian,Fu, Wenqiang,Deng, Wei,Xiang, Jiannan
supporting information, p. 1251 - 1254 (2016/12/27)
A general atom-economical approach for the synthesis of α-halomethyl ketones is demonstrated through Ce(SO4)2/acid co-catalyzed hydration of a wide range of haloalkynes. The reactions are conducted under convenient conditions and provide products with excellent regioselectivity in good to excellent yields, with broad substrate scope. This protocol is an alternative to conventional α-halogenation of ketones.
Design and synthesis of 2-acylbenzothiazoles via in situ cross-trapping strategy from benzothiazoles with aryl ketones
Gao, Qinghe,Wu, Xia,Jia, Fengcheng,Liu, Meicai,Zhu, Yanping,Cai, Qun,Wu, Anxin
, p. 2792 - 2797 (2013/04/24)
An I2/KOH synergistically promoted direct ring-opening aroylation of benzothiazoles with aryl ketones has been discovered. Aryl ketones were seen to act as carbonyl sources to construct 2-acylbenzothiazoles. This reaction could provide an example for the convergent integration of self-labor domino sequences based on an in situ cross-trapping strategy.
A direct method for the synthesis of indolizine derivatives from easily available aromatic ketones, pyridines, and acrylonitrile derivatives
Cai, Qun,Zhu, Yan-Ping,Gao, Yang,Sun, Jing-Jing,Wu, An-Xin
supporting information, p. 414 - 419 (2013/07/25)
A concise and efficient strategy has been proposed to synthesize indolizine derivatives from easily available aryl or heteroaryl methyl ketones, pyridines, and acrylonitriles. The mechanistic pathway involved the integration of iodination, pyridinium ylid
Highly efficient and clean method for direct α-iodination of aromatic ketones
Yin, Guodong,Gao, Meng,She, Nengfang,Hu, Shengli,Wu, Anxin,Pan, Yuanjiang
, p. 3113 - 3116 (2008/09/16)
Under neutral reaction conditions, aromatic ketones were transformed into the corresponding α-iodo ketones in high yields by the combination of copper(II) oxide and iodine. The reaction mechanism showed that copper(II) oxide played multiple roles through random self-sorting. Georg Thieme Verlag Stuttgart.
Kinetics of Iodination of Ketones by N-Iodosuccinimide in Acid Medium
Radhakrishnamurti, P. S.,Mahapatro, D. K.
, p. 207 - 210 (2007/10/02)
The kinetics of iodination of some ketones by N-iodosuccinimide (NIS) has been studied in aq. acetic acid medium in the presence of HClO4.The reaction is acid-catalysed exhibiting first order dependence with respect to acid.The reaction shows first order dependence with respect to and zero order dependence with respect to , indicating the acid-catalysed enolisation of ketones as the rate-determining step and reaction between enol and NIS as the fast step.The decrease in dielectric constant of the medium slightly enhances the reaction rate.The ρ, ?-relationship in the case of acetophenones is quite linear with ρ = -0.5 indicating the simultaneous operation of equilibrium protonation of ketones and deprotonation of the conjugate acid.The ρ, ?* plot of the different aliphatic ketones is also linear.The order of reactivity of different cyclic ketones studied is cyclohexanone ca. cyclooctanone > cyclopentanone > cycloheptanone.Arrhenius parameters have been computed and the observed isoenthalpic relationship has been discussed.A mechanism consistent with the results has been proposed.
