1828-76-8Relevant academic research and scientific papers
Selective oxidation of acetophenones bearing various functional groups to benzoic acid derivatives with molecular oxygen
Nakamura, Ryota,Obora, Yasushi,Ishii, Yasutaka
experimental part, p. 1677 - 1684 (2011/02/25)
Acetophenones substituted by alkyl, alkoxy, acetoxy, and halogen groups were selectively oxidized with molecular oxygen to the corresponding benzoic acids by using the N,N',N"-trihydroxyisocyanuric acid (THICA)/cobalt(II) acetate [Co(OAc)2] and THICA/Co(OAc)2/manganese(II) acetate.
Process for production of 3-hydroxy-3-methylphthalide or the nuclearly substituted derivatives thereof
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, (2008/06/13)
A process for producing 3-hydroxy-3-methylphthalide or its nuclearly substituted derivative of the following general formula STR1 wherein R represents a lower alkyl group, a lower alkoxy group, a lower alkoxycarbonyl group or a carboxyl group, and n is 0 or an integer of 1 to 3, which comprises reacting phthalic anhydride or its nuclearly substituted derivative of the following general formula STR2 wherein R and n are as defined, with malonic acid at an elevated temperature in at least one solvent selected from the group consisting of dialkylformamides, dialkylsulfoxides and aliphatic lower carboxylic acids in the presence of, as a catalyst, a salt of an inorganic or organic acid with a metal selected from the group consisting of metals of Groups IA, IIA, IIIB and VIII of the periodic table, manganese, copper and zinc.
