182878-97-3

Basic information

• Product Name: 6-[2-(2,5-Dimethoxyphenyl)ethyl]-4-ethylquinazoline
• Synonyms: LAV-694; SDZ-LAV-694
• CAS NO: 182878-97-3
• Molecular Formula: C₂₀H₂₂N₂O₂
• Molecular Weight: 322.41054
• Mol File: 182878-97-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-[2-(2,5-Dimethoxyphenyl)ethyl]-4-ethylquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[2-(2,5-Dimethoxyphenyl)ethyl]-4-ethylquinazoline(182878-97-3)
• EPA Substance Registry System: 6-[2-(2,5-Dimethoxyphenyl)ethyl]-4-ethylquinazoline(182878-97-3)

Safety Data

• Hazardous Substances Data: 182878-97-3(Hazardous Substances Data)

Upstream product

• 7440-05-3 palladium 

Relevant articles and documents

A practical synthesis of 6-[2-(2,5-dimethoxyphenyl)ethyl]-4-ethylquinazoline and the art of removing palladium from the products of Pd-catalyzed reactions

A concise large-scale synthesis of 1, a new antimitotic agent is described. The key step was a one-pot Sonogashira cross-coupling of an aryl halide with a heteroaryl halide through an acetylene using the readily available 2-methyl-3-butyn-2-ol (7). An innovative approach for palladium removal was designed and successfully scaled-up on a multikilogram scale. The product was crystallized from the crude reaction mixture while keeping the residual palladium in the mother liquor by using Pd-scavenging agents such as N-acetylcysteine or thiourea.