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182878-97-3

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182878-97-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 182878-97-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,2,8,7 and 8 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 182878-97:
(8*1)+(7*8)+(6*2)+(5*8)+(4*7)+(3*8)+(2*9)+(1*7)=193
193 % 10 = 3
So 182878-97-3 is a valid CAS Registry Number.

182878-97-3Upstream product

182878-97-3Downstream Products

182878-97-3Relevant articles and documents

A practical synthesis of 6-[2-(2,5-dimethoxyphenyl)ethyl]-4-ethylquinazoline and the art of removing palladium from the products of Pd-catalyzed reactions

Koenigsberger, Kurt,Chen, Guang-Pei,Wu, Raeann R.,Girgis, Michael J.,Prasad, Kapa,Repic, Oljan,Blacklock, Thomas J.

, p. 733 - 742 (2003)

A concise large-scale synthesis of 1, a new antimitotic agent is described. The key step was a one-pot Sonogashira cross-coupling of an aryl halide with a heteroaryl halide through an acetylene using the readily available 2-methyl-3-butyn-2-ol (7). An innovative approach for palladium removal was designed and successfully scaled-up on a multikilogram scale. The product was crystallized from the crude reaction mixture while keeping the residual palladium in the mother liquor by using Pd-scavenging agents such as N-acetylcysteine or thiourea.

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