18288-48-7Relevant academic research and scientific papers
Selective C-4 alkylation of pyridine by nickel/Lewis acid catalysis
Nakao, Yoshiaki,Yamada, Yuuya,Kashihara, Natsuko,Hiyama, Tamejiro
, p. 13666 - 13668 (2010)
Direct C-4-selective addition of pyridine across alkenes and alkynes is achieved for the first time by nickel/Lewis acid cooperative catalysis with an N-heterocyclic carbene ligand. A variety of substituents on both alkenes and pyridine are tolerated to give linear 4-alkylpyridines in modest to good yields. The addition across styrene, on the other hand, gives branched 4-alkylpyridines. A single example of C-4-selective alkenylation is also described.
