182884-03-3Relevant academic research and scientific papers
New non peptidic C5a receptor antagonists
Astles, Peter C.,Brown, Thomas J.,Cox, Paul,Halley, Frank,Lockey, Peter M.,McCarthy, Clive,McLay, Iain M.,Majid, Tahir N.,Morley, Andrew D.,Porter, Barry,Ratcliffe, Andrew J.,Walsh, Roger J.A.
, p. 907 - 912 (2007/10/03)
A series of phenylguanidines which bind to the C5a receptor has been developed. The lead compound 1 (IC50 = 30 μM), discovered through random screening, has been modified to provide 32 (RPR121154) with submicromolar activity. This compound was
Conversion of anilines to bis-Boc protected N-methylguanidines
Lammin, Simon G.,Pedgrift, Brian L.,Ratcliffe, Andrew J.
, p. 6815 - 6818 (2007/10/03)
The reaction of a variety of anilines with a new N-methylguanylating agent 5 to produce bis-Boc protected N-methylguanidines is reported.
