182887-79-2Relevant academic research and scientific papers
Aza-β3-cyclotetrapeptides
Salauen, Arnaud,Mocquet, Clemence,Perochon, Romain,Lecorgne, Aurelien,Le Grel, Barbara,Potel, Michel,Le Grel, Philippe
supporting information; experimental part, p. 8579 - 8582 (2009/04/04)
(Figure Presented) The cyclization of aza-β3-tetrapeptides gives access to new CTP (cyclotetrapeptide) analogues. These stereocontrolled templates are assembled without any asymmetric synthesis. X-ray crystallographic structure and NMR analysis show that the macrocyclic scaffold is characterized by a fully cooperative intramolecular H-bond network, in sharp contrast with the nanotubular assemblies observed for β3-cyclotetrapeptides. This folding property reduces considerably the polarity of aza-β3- tetrapeptides and should be useful in addressing intracellular targets.
