18289-63-9Relevant academic research and scientific papers
Exploration of the molecular origin of the azinomycin epoxide: Timing of the biosynthesis revealed
Sharma, Vasudha,Kelly, Gilbert T.,Watanabe, Coran M. H.
supporting information; experimental part, p. 4815 - 4818 (2009/05/31)
(Equation Presented) Streptomyces sahachiroi whole cell feeding experiments, utilizing putative precursors labeled with stable isotopes, established that the epoxide unit of the DNA cross-linked agents, azinomycin A and B, proceeds via a valine-dependent pathway and that hydroxylation and dehydration precedes formation of the terminal epoxide. Sodium 3-methyl-2-oxobutenoate, formed through a transimination reaction, was shown to be the penultimate precursor incorporated into the azinomycin epoxide.
A Highly Chemoselective Reduction of Conjugated Nitro Olefins with Hantzsch Ester in the Presence of Silica Gel
FUJI, Masayuki
, p. 4029 - 4036 (2007/10/02)
An effective system to reduce conjugated nitro olefins into the corresponding nitroalkanes is described.The system composed Hantzsch ester (HEH) and silica gel in benzene exerts high yield and excellent chemoselectivity under almost neutral conditions.Facile applications of the system to the syntheses of natural products are also described.
