18291-77-5Relevant academic research and scientific papers
Potassium Alkylpentafluorosilicates, Primary Alkyl Radical Precursors in the C-1 Alkylation of Tetrahydroisoquinolines
Wang, Teng,Wang, Dong-Hui
, p. 3981 - 3985 (2019)
In this study, we demonstrate that potassium alkylpentafluorosilicates (RSiF5K2) are efficient primary alkyl radical precursors for selective C(sp3)-C(sp3) bond-forming reactions. RSiF5K2 reagents are white, free-flowing solids and are moisture and air stable. This class of reagents enables the direct C-1 alkylation of tetrahydroisoquinolines under mild conditions via single-electron transfer. The broad substrate scope of both alkylpentafluorosilicates and tetrahydroisoquinolines is tolerated in this transformation. Both radical scavenger and EPR capture experiments show that the primary radical is generated by the oxidation of RSiF5K2. A mechanism involving alkyl radical addition to an iminium salt followed by reduction by an amine is proposed.
Catalysis in the core of a carbosilane dendrimer
Oosterom, G. Eric,Van Haaren, Richard J.,Reek, Joost N. H.,Kamer, Paul C. J.,Van Leeuwen, Piet W. N. M.
, p. 1119 - 1120 (2007/10/03)
The synthesis of a series of diphosphine ligands having phosphorus donor atoms in the core of a carbosilane dendrimer and their use in palladium catalysed allylic alkylation is described.
