182920-37-2

Upstream product

• 624-31-7 4-tolyl iodide 
• 189008-33-1 2-[2-(4-methylphenyl)ethynyl]benzaldehyde 
• 38846-64-9 2-ethynylbenzaldehyde 
• 1079-66-9 chloro-diphenylphosphine 
• 171070-83-0 1-(2-(p-tolylethynyl)phenyl)hept-2-yn-1-ol 

Relevant academic research and scientific papers

Switching from the Myers Reaction to a New Thermal Cyclization Mode in Enyne-Allenes

Through variation of the substituents at the acetylene terminus in enyne-allenes the reaction mode may be changed from the Myers- to a novel C-2-C-6 cyclization reaction.This thermal cyclization of acyclic enyne-allenes in high yields allows the synthesis

A surprising switch from the Myers-Saito cyclization to a novel biradical cyclization in enyne-allenes: Formal diels-alder and ene reactions with high synthetic potential

If there is an aryl substituent on the acetylene terminus of enyne allenes, then its reaction mode may be changed from the Myers-Saito cyclization to a novel C2-C6 cyclization resulting in a net intramolecular Diels-Alder or ene reaction. As a consequence, the thermal cyclization of readily accessible acyclic enyne allenes can be utilized for the synthesis of complex benzofulvene and benzofluorene derivatives. Kinetic results of the C2-C6 cyclization reaction indicate a two-step reaction pathway with a benzofulvene biradical intermediate.