182925-69-5Relevant academic research and scientific papers
Kinetic investigation on aqueous decomposition of 2- chloroethylnitrososulfamide
Seridi, Achour,Kadri, Mekki,Abdaoui, Mohamed,Winum, Jean-Yves,Montero, Jean-Louis
, p. 1021 - 1027 (2007/10/03)
The kinetics decomposition of 2-chloroethylnitrososulfamides (CENS) was studied in aqueous buffered solutions with pH ranging from 0 to 14. The study was monitored by RP-LC-MS and conventional UV spectrophotometry. The reaction proceeded via a pseudo-firs
Study on the decomposition of 2-chloroethylnitrososulfamides (CENS) in serum using HPLC on-line solid phase extraction
Seridi, Achour,Winum, Jean-Yves,Kadri, Mekki,Abdaoui, Mohamed,Montero, Jean-Louis
, p. 521 - 526 (2007/10/03)
In this paper we have investigated the kinetic decomposition of 2-chloroethylnitrososulfamides (CENS) in fetal calf serum. The study was monitored by on-line solid phase extraction linked to RP-LC-MS. We demonstrated that CENS are less stable in fetal calf serum than in aqueous buffer at pH 7.4 and 37°C. Moreover, we have shown that partition coefficient of CENS can be correlated to the kinetics decomposition, and we observe that the stability is better for lipophilic CENS. The different metabolites after decomposition have been tentatively identified by RP-HPLC-MS. This study indicates the formation of several metabolites resulting from a mechanism of decomposition more complex than in aqueous phosphate buffer, nevertheless, leading to the same main products.
A new family of potential oncostatics: 2-Chloroethylnitrososulfamides (CENS) - I. Synthesis, structure, and pharmacological evaluation (preliminary results)
Abdaoui, Mohamed,Dewynter, Georges,Aouf, Nourredine,Favre, Gilles,Morere, Alain,Montero, Jean-Louis
, p. 1227 - 1235 (2007/10/03)
A new series of alkylating agents, 2-chloroethylnitrososulfamides (CENS), were developed on the model of 2-chloroethylnitrosoureas. Starting from chlorosulfonyl isocyanate, a four-step synthesis (carbamoylation-sulfamoylation, Mitsunobu alkylation, deprotection, and nitrosation) gives the title compounds in a 47-58% overall yield. The selection of the nitrosation site can be directed through an alternative route. The pharmacological evaluation shows a significant oncostatic activity towards both A549 and MCF7 cell lines.
