182948-74-9Relevant academic research and scientific papers
1,4-Arylation of β-aroylacrylic acids with thiophene and utilization of the products in synthesis of some heterocycles
Amine,El-Hashash,Soliman,Soliman
, p. 1097 - 1100 (2007/10/03)
β-Aroylacrylic acids react with thiophene in boiling benzene to give α-(2-thienyl)- β-aroylpropionic acids (1a-c). The reactions of 1c with hydrazine hydrate, hydroxylamine hydrochloride, semicarbazide hydrochloride, aromatic aldehydes, and acetic anhydride yield pyridazinone 2, oxazinone 3, semicarbazone 4, arylidene propionic acids (5a-c) and furanones (6a-c), respectively. The reactions of compound 6c with some nitrogen nucleophiles and aromatic hydrocarbons under Friedel Crafts' conditions have also been discussed.
