182965-69-1Relevant academic research and scientific papers
Silylation-based kinetic resolution of monofunctional secondary alcohols
Sheppard, Cody I.,Taylor, Jessica L.,Wiskur, Sheryl L.
supporting information; experimental part, p. 3794 - 3797 (2011/10/02)
The nucleophilic small molecule catalyst (-)-tetramisole was found to catalyze the kinetic resolution of monofunctional secondary alcohols via enantioselective silylation. Optimization of this new methodology allows for selectivity factors up to 25 utilizing commercially available reagents and mild reaction conditions.
Cobalt-catalyzed oxidative kinetic resolution of secondary benzylic alcohols with molecular oxygen
Yamada, Tohru,Higano, Sho,Yano, Takanori,Yamashita, Yoshihiro
supporting information; experimental part, p. 40 - 41 (2009/12/03)
The oxidative kinetic resolution of secondary alcohols using molecular oxygen and olefins was catalyzed by the optically active ketoiminatocobalt(II) complexes. The various secondary benzylic alcohols were subjected to the aerobic oxidative reaction to afford optically active alcohols of high ee along with the corresponding ketones in high yield. The oxidation of the deuterated alcohols revealed that the accompanying olefin mediated the oxidation for conversion to the corresponding α-deuterated ketones. Copyright
