182998-53-4Relevant academic research and scientific papers
Enantiomerically pure α-fluoroalkyl-α-amino acids: Synthesis of (R)-α-difluoromethyl-alanine and (S)-α-difluoromethyl-serine
Bravo, Pierfrancesco,Capelli, Silvia,Meille, Stefano V.,Seresini, Paolo,Volonterio, Alessandro,Zanda, Matteo
, p. 2321 - 2332 (2007/10/03)
Hydrocyanation of enantiomerically pure N-Cbz α-fluoroalkyl β-sulfinylenamines 1 occurs smoothly by treatment with KCN or by addition of trimethylsilylcyanide or diethyl phosphorocyanidate to preformed sodium derivatives of 1. The diastereoisomeric difluoro α-aminonitriles 2b have been transformed in the unnatural amino acids (R)-α-difluoromethyl-alanine and (S)-α-difluoromethyl-serine.
