1830-93-9Relevant academic research and scientific papers
Pd(OAc)2-catalyzed orthogonal synthesis of 2-hydroxybenzoates and substituted cyclohexanones from acyclic unsaturated 1,3-carbonyl compounds
Miyagi, Toshinori,Okada, Sho,Tada, Naoya,Sugihara, Masahiro,Kagawa, Natsuko,Takabatake, Tetsuhiko,Toyota, Masahiro
, p. 1653 - 1657 (2019/05/29)
A Pd-catalyzed orthogonal synthesis of substituted 2-hydroxybenzoates and substituted cyclohexanones was developed for the first time. The substituted 2-hydroxybenzoates were obtained from acyclic unsaturated 1,3-carbonyl compounds using a combination of catalytic Pd(OAc)2 and Cu(OAc)2. On the other hand, the substituted cyclohexanones were produced from similar substrates via catalytic Pd(OAc)2 and hydrogen chloride. Each transformation was clean, easy to work up, provided the desired compounds in good purities, and did not require column chromatography purification.
ON THE MECHANISM OF THE MANDER CARBOMETHOXYLATION OF KETONE ENOLATES WITH METHYL CYANOFORMATE
Ziegler, Frederick E.,Wang, Tein-Fu
, p. 2291 - 2292 (2007/10/02)
The acylation of lithium enolates of ketones with methyl cyanoformate has been shown to proceed through an aldol-type intermediate that can be trapped at low temperature.
