183075-06-1Relevant academic research and scientific papers
Facile synthesis of 2',3'-unsaturated nucleosides from 2-deoxyribose
Sujino, Keiko,Yoshida, Tomoyasu,Sugimura, Hideyuki
, p. 6133 - 6136 (2007/10/03)
A straightforward approach for the synthesis of 2',3'-unsaturated nucleosides starting from 2-deoxyribose is described. This novel route involves two new methods; (1) preparation of 2-deoxy-1-thioribofuranoside by direct condensation of 2-deoxyribose and thiophenol, (2) formation of the nucleoside skeleton by the direct coupling of 2,3-unsaturated 1-thiopentofuranoside with pyrimidine bases.
β-Anomer selectivity in 2′-deoxynucleoside synthesis: A novel approach using an acyl carbamate directing group
Young, Robert J.,Shaw-Ponter, Sue,Hardy, George W.,Mills, Gail
, p. 8687 - 8690 (2007/10/02)
Glycosylation of silylated pyrimidines using a phenyl 2-deoxy-3-O-(N-benzoyl)carbamoyl-1-thio-D-erythro-pentofuranoside yielded 2-deoxy-β-ribonucleosides in good yields with excellent anomeric selectivity. This prototype 3-O-carbamate directing group was readily formed and removed in high yields.
