183133-99-5

Basic information

• Product Name: 7,13-Bis-O-(triethylsilyl)-10-deacetyl Baccatin III
• Synonyms: 7,13-Bis-O-(triethylsilyl)-10-deacetyl Baccatin III
• CAS NO: 183133-99-5
• Molecular Formula: C₄₁H₆₄O₁₀Si₂
• Molecular Weight: 773.11186
• Product Categories: Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 183133-99-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate
• CAS DataBase Reference: 7,13-Bis-O-(triethylsilyl)-10-deacetyl Baccatin III(CAS DataBase Reference)
• NIST Chemistry Reference: 7,13-Bis-O-(triethylsilyl)-10-deacetyl Baccatin III(183133-99-5)
• EPA Substance Registry System: 7,13-Bis-O-(triethylsilyl)-10-deacetyl Baccatin III(183133-99-5)

Safety Data

• Hazardous Substances Data: 183133-99-5(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

As 10-Deacetylbaccatin III (D198250) derivative, 7,13-Bis-O-(triethylsilyl)-10-deacetyl Baccatin III can be used in the preparation of taxol analogs with antitumoral and antineoplastic properties.

Upstream product

• 32981-86-5 10-deacetylbaccatin III 
• 994-30-9 triethylsilyl chloride 

Downstream Products

• 183133-98-4 4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β-hydroxy-9-oxo-10β-methoxy-7β,13α-di(triethylsilyloxy)-11-taxene 
• 183133-94-0 4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene 
• 1433749-82-6 4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,7β-dihydroxy-9-oxo-10β-methoxy-13α-triethylsilyloxy-11-taxene 
• 1396601-24-3 4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β-hydroxy-7β,10β-dimethoxy-9-oxo-13-(triethylsilyloxy)-11-taxene 
• 183133-96-2 carbazitaxel 
• 1402820-62-5 (αR, βS)-α-hydroxy-β-[[(1,1-dimethylethoxy)carbonyl]amino]benzene-propanoic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,1112,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester isopropanol solvate 
• 237428-99-8 C₇₁H₁₀₄O₂₀Si₂ 

Relevant articles and documents

Preparation method of 7beta,10beta-dimethoxy-10-deacetylbaccatin III

The invention relates to a preparation method of 7beta,10beta-dimethoxy-10-deacetylbaccatin III. Particularly, the method provided by the invention takes acetylbaccatin as a raw material and comprises a series of the following steps: protecting through silicon protecting groups at a 7 site and a 13 site; selectively removing the silicon protecting group at the 7 site; directly alkylating at the 7 site and a 10 site; and finally, removing the silicon protecting group at the 13 site to prepare a taxane compound, namely the 7beta,10beta-dimethoxy-10-deacetylbaccatin III shown as a formula V. (The formula V is shown in the description.).

PROCESSES FOR THE PREPARATION OF CABAZITAXEL INVOLVING C(7) -OH AND C(13) -OH SILYLATION OR JUST C(7) -OH SILYLATION

Disclosed are processes towards Cabazitaxel (I) starting from 10-Deacetylbaccatin (III) that involve steps of either 7-OH monosilylation (passing through formula V) or 7,13-disilylation (passing through formulae XI, XII). Isopropanol Solvates of Cabazitaxel and processes to make this are also described.