183179-19-3

Upstream product

• 621-29-4 3-tolyl isocyanate 
• 205694-33-3 methyl 2-{3-[N-(2-aminoacetyl)-N-(N-methyl-N-phenylcarbamoylmethyl)amino]phenoxy}acetate 
• 554-84-7 meta-nitrophenol 
• 158196-47-5 methyl 2-(3-aminophenoxy)acetate 
• 205694-26-4 methyl 2-(3-{N-[2-(N-tert-butoxycarbonylamino)acetyl]-N-(N-methyl-N-phenylcarbamoylmethyl)amino}phenoxy)acetate 
• 205694-16-2 methyl 2-(3-{N-[2-(N-tert-butoxycarbonylamino)acetyl]amino}phenoxy)acetate 
• 81720-19-6 1-methoxycarbonylmethyloxy-3-nitrobenzene 

Downstream Products

• 205694-39-9 2-[3-(N-(N-methyl-N-phenylcarbamoylmethyl)-N-{2-[3-(3-methylphenyl)ureido]acetyl}amino)phenoxy]acetic acid 

Relevant academic research and scientific papers

Aminophenol derivatives

Aminophenol derivatives represented by the following formula (1): STR1 wherein X is O or S; A is alkylene, R 1 is phenyl, etc., R 2 and R 3 are H or alkyl; R 4 is substituted carbamoylalkyl, etc.; R 5 is substituted amino, etc.; their salts, and optical i

Synthesis of phenoxyacetic acid derivatives as highly potent antagonists of gastrin/cholecystokinin-B receptors

A novel series of phenoxyacetic acid derivatives was synthesized based on considerations of the three-dimensional structural similarity of YM022 and RP72540. The gastrin/cholecystokinin (CCK)-B and CCK-A receptor antagonist activities of these compounds were evaluated by investigation of their affinities for human gastrin/CCK-B receptors and human CCK-A receptors, respectively. It was found that N-methyl-N-phenyl-2-[2-[N-(N-methyl-N- phenyl-carbamoylmethyl)-N-[2-[3-(3- methylphenyl)ureido]acetyl]amino]phenoxy]acetamide (20k, DZ-3514) exhibited high affinity for gastrin/CCK-B receptors and high selectivity over CCK-A receptors.