183181-59-1Relevant academic research and scientific papers
Synthesis of (R)- and (S)-β-hydroxyphosphonate acyclonucleosides: Structural analogues of Adefovir (PMEA)
Kasthuri, Mahesh,Chaloin, Laurent,Perigaud, Christian,Peyrottes, Suzanne
, p. 1505 - 1511 (2011)
A synthetic pathway to new acyclonucleoside phosphonates, as analogues of Adefovir, is described. The reduction of an acyclonucleoside β-ketophosphonate, readily available from the nucleobase and benzylacrylate, afforded a mixture of (R)- and (S)-β-hydrox
