183197-80-0Relevant articles and documents
Tetrahydrofuran Ring-Containing Nucleotide Analogs Related to HPMPA and PMEA
Liboska, Radek
, p. S72 - S75 (2007/10/03)
Synthesis of 9-N-(4-(phosphonomethoxy)tetrahydrofuran-3-yl)adenine derivatives, a novel type of nucleotide analogs related to (R)- and (S)-9-N-(3-hydroxy-2-phosphonomethoxypropyl)adenine ((R)- and (S)-HPMPA) and 9-(2-phosphonomethoxyethyl)adenine (PMEA), is described.The synthesis of adenine nucleotide analogs 6a-6d is based on the reaction of 6-N-protected adenine derivatives 5a-5d with diisopropyl tosyloxymethanephosphonate and subsequent deprotection of resulting compounds.The starting "nucleoside" derivatives have been prepared from chiral 4-benzyloxytetrahydrofuran-3-ols 3a-3d.