183211-06-5Relevant academic research and scientific papers
α-(benzotriazol-1-yl)propargyl ethyl ethers: Novel precursors to enediynes, enynes and dienynes
Katritzky, Alan R.,Zhang, Zhongxing,Lang, Hengyuan
, p. 4049 - 4064 (2007/10/03)
Deprotonated 1-(benzotriazol-1-yl)propargyl ethyl ethers react with propargyl, allyl and alkyl bromides to give the expected substituted derivatives 2, 4 and 9, respectively. Subsequent eliminations of the benzotriazolyl group upon treatment with NaH or ZnBr2, and elaboration of the acetylene group, generate ethoxy substituted enediynes 3, 6, 8, dienynes 7 and enynes 12. Grignard reagents or LiAlH4 convert 9 into 2a-ethoxy substituted alkynes 10 and 11.
