183235-14-5Relevant academic research and scientific papers
Preparation of aromatic amides from carbon monoxide, an amine and an aromatic chloride
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, (2008/06/13)
The present invention is directed to a process for preparing an aromatic amide. More specifically, the process involves reacting carbon monoxide, an amine and an aromatic chloride in the presence of an iodide or bromide salt, a catalyst, and a base.
Palladium-catalyzed carbonylation and coupling reactions of aryl chlorides and amines
Perry, Robert J.,Wilson, B. David
, p. 7482 - 7485 (2007/10/03)
The palladium-catalyzed amidation of electron-deficient aryl chlorides proceeds readily in the presence of low CO pressures and a slight excess of an iodide salt. The rates of amidation are accelerated over those without added salt, and iodide is preferred over bromide or chloride. More electron-rich aryl chlorides were not effectively amidated, either with or without added iodide. We postulate that an intermediate anionic palladium(0) iodide complex is responsible for the enhanced reactivity.
