18324-22-6

Basic information

• Product Name: Uracil, dimer, syn- (8CI)
• Synonyms: Uracil, dimer, syn- (8CI)
• CAS NO: 18324-22-6
• Molecular Formula: (C4H4N2O2)2
• Molecular Weight: 112.09
• Product Categories: PYRIMIDINE
• Mol File: 18324-22-6.mol
• Article Data: 156

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Uracil, dimer, syn- (8CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Uracil, dimer, syn- (8CI)(18324-22-6)
• EPA Substance Registry System: Uracil, dimer, syn- (8CI)(18324-22-6)

Safety Data

• Hazardous Substances Data: 18324-22-6(Hazardous Substances Data)

Upstream product

• 3257-75-8 1-(2,5-Anhydro-β-D-arabinofuranosyl)pyrimidin-2,4(1H,3H)-dione 
• 591-28-6 4-thiouracil 
• 97-67-6 (S)-Malic acid 
• 7664-93-9 sulfuric acid 
• 57-13-6 urea 
• 928-01-8 maleamide 
• 1448-98-2 N-(aminocarbonyl)-2-cyano-acetamide 
• 7732-18-5 water 
• 122-51-0 orthoformic acid triethyl ester 
• 1758-73-2 Aminoiminomethanesulfinic acid 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 617-48-1 malic acid 
• 141-90-2 2-thiouracil 
• 2758-06-7 (2-bromoethyl)trimethylammonium bromide 

Downstream Products

• 40338-28-1 1-acetyl-1H-pyrimidine-2,4-dione 
• 13964-47-1 5-fluoro-6-methoxy-5,6-dihydrouracil 
• 7236-71-7 1-but-3-enyl-1H-pyrimidine-2,4-dione 
• 132416-94-5 1,3-Di-but-3-enyl-1H-pyrimidine-2,4-dione 
• 22390-04-1 1,3-diethyluracil 
• 79719-29-2 1,3-dihydroxymethyluracil 
• 143541-91-7 1-(2-cyclopentenyl)uracil 
• 78097-04-8 1-[(2-hydroxyethoxy)methyl]uracil 
• 4449-38-1 2'-deoxy-3',5'-di-O-(4-methylbenzoyl)uridine 
• 4449-37-0 1-[O³,O⁵-bis-(4-methyl-benzoyl)-α-D-erythro-2-deoxy-pentofuranosyl]-1H-pyrimidine-2,4-dione 
• 148058-43-9 1,7,11,17-Tetraaza-tricyclo[15.3.1.1^7,11]docosa-9,19-diene-8,18,21,22-tetraone 
• 148058-52-0 1,7,11,17-Tetraaza-tricyclo[15.3.1.1^7,11]docosa-9,18-diene-8,20,21,22-tetraone 
• 21416-43-3 L-willardiine 
• 21381-33-9 L-isowillardiine 

Relevant articles and documents

Structural Evidence for a [4Fe-5S] Intermediate in the Non-Redox Desulfuration of Thiouracil

We recently discovered a [Fe-S]-containing protein with in vivo thiouracil desulfidase activity, dubbed TudS. The crystal structure of TudS refined at 1.5 ? resolution is reported; it harbors a [4Fe-4S] cluster bound by three cysteines only. Incubation of TudS crystals with 4-thiouracil trapped the cluster with a hydrosulfide ligand bound to the fourth non-protein-bonded iron, as established by the sulfur anomalous signal. This indicates that a [4Fe-5S] state of the cluster is a catalytic intermediate in the desulfuration reaction. Structural data and site-directed mutagenesis indicate that a water molecule is located next to the hydrosulfide ligand and to two catalytically important residues, Ser101 and Glu45. This information, together with modeling studies allow us to propose a mechanism for the unprecedented non-redox enzymatic desulfuration of thiouracil, in which a [4Fe-4S] cluster binds and activates the sulfur atom of the substrate.

Green production process of uracil

The invention relates to the field of chemistry, and particularly provides a green production process of uracil, which comprises the following steps: cyclizing 3-alkoxy (amino) acrylate (amide) and urea alkali metal salt, acidifying, and converting into uracil with the yield of more than 95%.

Anion exchange resins in phosphate form as versatile carriers for the reactions catalyzed by nucleoside phosphorylases

In the present work, we suggested anion exchange resins in the phosphate form as a source of phosphate, one of the substrates of the phosphorolysis of uridine, thymidine, and 1-(β-D-arabinofuranosyl)uracil (Ara-U) catalyzed by recombinant E. coli uridine (UP) and thymidine (TP) phosphorylases. α-D-Pentofuranose-1-phosphates (PF-1Pis) obtained by phosphorolysis were used in the enzymatic synthesis of nucleosides. It was found that phosphorolysis of uridine, thymidine, and Ara-U in the presence of Dowex 1X8 (phosphate; Dowex-nPi) proceeded smoothly in the presence of magnesium cations in water at 20-50 °C for 54-96 h giving rise to quantitative formation of the corresponding pyrimidine bases and PF-1Pis. The resulting PF-1Pis can be used in three routes: (1) preparation of barium salts of PF-1Pis, (2) synthesis of nucleosides by reacting the crude PF-1Pi with an heterocyclic base, and (3) synthesis of nucleosides by reacting the ionically bound PF-1Pi to the resin with an heterocyclic base. These three approaches were tested in the synthesis of nelarabine, kinetin riboside, and cladribine with good to excellent yields (52-93%).