18327-79-2Relevant academic research and scientific papers
Solid-phase oxidation of 2,4-di-tert-butylphenol and 3,6-di-tert-butylpyrocatechol in the presence of alkali and alkaline earth metal halides under elastic deformation
Vol'eva,Prokof'ev,Belostotskaya,Karmilov,Komissarova,Prokof'eva,Ershov
, p. 847 - 850 (2000)
Solid-phase oxidation of 2,4-di-tert-butylphenol to give 2,2′,4,4′-tert-butyl-6,6′-bisphenol and of 3,6-di-tert-butylpyrocatechol to afford 3,6-di-tert-butyl-1,2-benzoquinone was performed in the presence of alkali and alkaline earth metals halides under conditions of modified extrusion. The formation of the corresponding metal 3,6-di-tert-butylsemiquinolates was registered by ESR method. The different behavior of chlorides, bromides, and iodides was observed and rationalized basing on the dissimilar complexing ability of halogens. The mechanism of activated oxidation was assumed.
Direct C-F bond formation using photoredox catalysis
Rueda-Becerril, Montserrat,Mahe, Olivier,Drouin, Myriam,Majewski, Marek B.,West, Julian G.,Wolf, Michael O.,Sammis, Glenn M.,Paquin, Jean-Francois
supporting information, p. 2637 - 2641 (2014/03/21)
We have developed the first example of a photoredox catalytic method for the formation of carbon-fluorine (C-F) bonds. The mechanism has been studied using transient absorption spectroscopy and involves a key single-electron transfer from the 3MLCT (triplet metal-to-ligand charge transfer) state of Ru(bpy)32+ to Selectfluor. Not only does this represent a new reaction for photoredox catalysis, but the mild reaction conditions and use of visible light also make it a practical improvement over previously developed UV-mediated decarboxylative fluorinations.
Discovery of potent transient receptor potential vanilloid 1 antagonists: Design and synthesis of phenoxyacetamide derivatives
Takahashi, Eiki,Hirano, Noriyuki,Nagahara, Takashi,Yoshikawa, Satoru,Momen, Shinobu,Yokokawa, Hiroshi,Hayashi, Ryoji
, p. 3154 - 3156 (2013/06/26)
We aimed to discover a novel type of transient receptor potential vanilloid 1 (TRPV1) antagonist because such antagonists are possible drug candidates for treating various disorders. We modified the structure of hit compound 7 (human TRPV1 IC50 = 411 nM) and converted its pyrrolidino group to a (hydroxyethyl)methylamino group, which substantially improved inhibitory activity (15d; human TRPV1 IC50 = 33 nM). In addition, 15d ameliorated bladder overactivity in rats in vivo.
Low plate-out polycarbonates
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, (2008/06/13)
Polycarbonate resins are chain-terminated with a group selected from those of the formula: STR1 wherein R1, R2 and R3 are each independently selected from the group consisting of hydrogen, halogen, hydrocarbyl of from 1 to
