18328-11-5

Basic information

• Product Name: 4-PHENYLBUTANAL
• Synonyms: PHENETHYL ACETALDEHYDE;PHENYLBUTYRALDEHYDE(4-);4-PHENYLBUTANAL;4-PHENYLBUTYRALDEHYDE;Benzenebutanal;Benzenebutyraldehyde;γ-Phenylbutyraldehyde
• CAS NO: 18328-11-5
• Molecular Formula: C₁₀H₁₂O
• Molecular Weight: 148.2
• Mol File: 18328-11-5.mol
• Article Data: 208

Chemical Properties

• Melting Point: 45-48 °C
• Boiling Point: 243.3°Cat760mmHg
• Flash Point: 115.9°C
• Appearance: /
• Density: 0.971g/cm³
• Vapor Pressure: 0.0323mmHg at 25°C
• Refractive Index: 1.504
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 4-PHENYLBUTANAL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENYLBUTANAL(18328-11-5)
• EPA Substance Registry System: 4-PHENYLBUTANAL(18328-11-5)

Safety Data

• Hazardous Substances Data: 18328-11-5(Hazardous Substances Data)

Usage

Uses

4-Phenylbutanal (cas# 18328-11-5) is a useful reactant for the synthesis of latanoprost via organocatalyzed [3+2]-cycloaddition. Latanoprost is a medication used to treat increased pressure inside the eye

Synthesis Reference(s)

Chemistry Letters, 21, p. 423, 1992Journal of the American Chemical Society, 108, p. 1325, 1986 DOI: 10.1021/ja00266a049Tetrahedron Letters, 34, p. 6505, 1993 DOI: 10.1016/0040-4039(93)88090-6

InChI:InChI=1/C10H12O/c11-9-5-4-8-10-6-2-1-3-7-10/h1-3,6-7,9H,4-5,8H2

Upstream product

• 57398-27-3 (3,3-diethoxy-propane-1-sulfonyl)-benzene 
• 100-44-7 benzyl chloride 
• 67-56-1 methanol 
• 768-56-9 4-Phenylbut-1-ene 
• 1126-76-7 1,2-Epoxy-4-phenylbutane 
• 591-50-4 iodobenzene 
• 627-27-0 homoalylic alcohol 
• 201230-82-2 carbon monoxide 
• 637-59-2 1-Bromo-3-phenylpropane 
• 65178-51-0 N-allyldiphenylamine 
• 133496-85-2 (E)-4-Diphenylamino-1,1-diphenyl-but-3-en-1-ol 
• 83486-18-4 C₂₂H₂₂Te₂ 
• 13214-66-9 4-phenyl-1-butylamine 
• 75-05-8 acetonitrile 

Downstream Products

• 102840-43-7 3-benzylhex-5-en-2-one 
• 94252-87-6 6-chloro-1,1-dioxo-3-(3-phenyl-propyl)-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide 
• 84299-17-2 ethyl (E)-6-phenylhex-2-enoate 
• 55283-02-8 methyl (E)-6-phenyl-2-hexenoate 
• 33046-76-3 methyl 6-phenylhex-2-enoate 
• 80313-86-6 2-Phenylseleno-4-phenylbutanal 
• 83379-04-8 (2S,3S)-3,5-Dimethyl-2-(3-phenyl-propyl)-2,3-dihydro-pyran-4-one 
• 83379-00-4 (2R,3S)-3,5-Dimethyl-2-(3-phenyl-propyl)-2,3-dihydro-pyran-4-one 
• 115942-35-3 7-phenyl-2(E)-hepten-4-ol 
• 127208-54-2 9-phenyl-cis-1,5-nonadiene 
• 127208-55-3 ((E)-Nona-4,8-dienyl)-benzene 
• 22632-23-1 (dl)-1,8-diphenyl-4,5-octanediol 
• 127208-57-5 10-phenyl-cis-1,6-decadiene 
• 14213-84-4 2-phenylethylstyrene 

Relevant articles and documents

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The preparation of tris(ethylenedioxyboryl)methane (2), the reagent for the only known homologation of aldehydes and ketones under non-acidic conditions, was improved by avoiding the difficult isolation of the intermediate tris(dimethoxyboryl)methane (1) and by direct crystallization of 2.

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The Co-catalyzed remote hydroboration and alkene isomerization of allylic siloxanes were realized by a ligand-controlled strategy. The remote hydroboration with dcype provided borylethers, while xantphos favored the formation of silyl enol ethers.

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