183281-47-2Relevant academic research and scientific papers
Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase
Ciccarone, Terrence M.,MacTough, Suzanne C.,Williams, Theresa M.,Dinsmore, Christopher J.,O'Neill, Timothy J.,Shah, Daksha,Culberson, J. Christopher,Koblan, Kenneth S.,Kohl, Nancy E.,Gibbs, Jackson B.,Oliff, Allen I.,Graham, Samuel L.,Hartman, George D.
, p. 1991 - 1996 (2007/10/03)
The design and syntheses of non-thiol inhibitors of farnesyl-protein transferase are described. Substitutions on an imidazolylmethyl-AMBA- methionine template gave a highly potent and cell-active inhibitor.
