183298-68-2Relevant articles and documents
Carbohydroxamido-oxazolidines: Antibacterial agents that target lipid a biosynthesis
Chen, Meng-Hsin,Steiner, Mark G.,De Laszlo, Stephen E.,Patchett, Arthur A.,Anderson, Matt S.,Hyland, Sheryl A.,Onishi, H. Russell,Silver, Lynn L.,Raetz, Christian R. H.
, p. 313 - 318 (1999)
A series of carbohydroxamido-oxazolidine inhibitors of UDP-3-O-[R-3- hydroxymyristoyl]-GlcNAc deacetylase, the enzyme responsible for the second step in lipid A biosynthesis, was identified. The most potent analog L- 161,240 showed an IC50 = 30 nM in the DEACET assay and displayed an MIC of 1 ~ 3 μ/mL against wild-type E. coli.